Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis The functional role of the co-presence of aberrant long non-coding RNAs (lncRNAs) and coding genes in cancer remains poorly understood. Here, the transcriptional regulator Prohibitin 2 (PHB2) is shown to...
Exposures The patient groups were (1) patients without cancer, (2) patients with no recent cancer treatment, and (3) patients with recent cancer treatment (within 3 months before COVID-19 diagnosis) consisting of radiation therapy or systemic therapy. Main Outcomes and Measures Mortality, mechanic...
The introduction of this miRNA leads to increased radiation and oxaliplatin sensitivity and inhibition of self-renewal. In EpCAM+ALDH+ cells derived from PDX, SNAI1 was upregulated, while miR-145 was downregulated which confirms the functionality of the axis in CSCs in vivo [120]. SIRT1-miR-...
judgemental lens, it allows one to reevaluate group members’ experience in a way that is consistent with their core values. The initial coding guide was developed based on Yalom’s [14] notion about existential awareness and acceptance as well as other acceptance-based literature [3,5,6,18,...
Increasing evidence shows that circular RNAs (circRNAs), a novel class of noncoding RNAs, play a crucial role in the development of cancers, including intrahepatic cholangiocarcinoma (iCCA). Nevertheless, their functions and exact mechanisms in iCCA progression and metastasis are still unclear. Ipatase...
Saarland Cancer Registry, Saarbrücken, Germany Christa Stegmaier Department of Obstetrics and Gynaecology, University of Melbourne and the Royal Women’s Hospital, Melbourne, Australia Jennifer Stone Division of Breast Cancer Research, The Institute of Cancer Research, London, UK Anthony Swerdlow Epigene...
9.3.1.1.15.non-coding RNA IN TCGA 9.3.1.1.25.downlaoding of TCGA datasets 9.3.1.1.TCGA(The Cancer Genome Atlas) The Cancer Genome Atlas (TCGA), a landmark cancer genomics program, molecularly characterized over 20,000 primary cancer and matched normal samples spanning 33 cancer types. This...
Both HPV+ and HPV- HNSCC are treated with a combination of surgery, radiation and adjuvant chemotherapy. Treatment specifics vary depending on anatomic site and disease stage. In general, low stage tumors are treated with surgery, followed by radiation if positive surgery margins are detected. For...
staging systems are the American Joint Committee on Cancer (AJCC) tumor, node, and metastasis (TNM) system, typically used in clinical settings, and the Surveillance, Epidemiology, and End Results (SEER) summary staging system, used for descriptive and statistical analysis of tumor registry data....
cancer immunity; epigenetic regulation; immune checkpoint; long non-coding RNAs; circular RNA1. Introduction Cancer is one of the most complex multifactorial human diseases. In 2020, 10 million people are estimated to have died from cancer [1], reflecting an ongoing need to discover new and ...