“By using both bulk and single cell approaches we get a better picture of what is going on and can start to examine the effects of genetic mutations on disease kinetics,” Leshchiner says. Tumour cells and beyond Single cell sequencing has applications beyond the actual tumour cells. There ...
One day, an anti-cancer agent could be a cell with specially equipped powerful balloons that pop when placed near an ultrasound beam(超声束)—killing surrounding cancer cells in its wake. The key to this operation are tiny protein bubbles. If a microbe(微生物) wishes to rise to the surface...
A mechanism for hypoxia-induced inflammatory cell death in cancer We find that PTP1B and ABL1/2 reciprocally control RNF213 tyrosine phosphorylation and its oligomerization and RZ domain activation, and identify a unique PTP1B–RNF213–CYLD–SPATA2 pathway critical for the control of inflammatory...
近日,中山大学邝栋明研究团队等在Cancer Cell上发表了题为Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma的研究。该研究结合多队列肝癌免疫治疗样本与单细胞测序、TCR 测序和空间转录组...
胶质母细胞瘤(Glioblastoma,GBM)是一种高度侵袭性的原发性脑肿瘤,胶质母细胞瘤干细胞(GSC)是胶质母细胞瘤中具有自我更新、驱动肿瘤进展、参与免疫逃逸的细胞。复杂的 GSC 免疫微环境是导致胶质母细胞瘤预后不良的最主要因素之一。 浆细胞(P...
胶质母细胞瘤(Glioblastoma,GBM)是一种高度侵袭性的原发性脑肿瘤,胶质母细胞瘤干细胞(GSC)是胶质母细胞瘤中具有自我更新、驱动肿瘤进展、参与免疫逃逸的细胞。复杂的 GSC 免疫微环境是导致胶质母细胞瘤预后不良的最主要因素之一。 浆细胞(Plasma cell,PC)是 B 细胞系免疫系统的关键效应细胞,但其在胶质母细胞瘤中...
《Cancer Cell》第 4 期封面是推动巨石的西西弗,象征淋巴瘤中 ARID1A 的作用。 淋巴瘤中常出现 ARID1A 突变。ARID1A 是经典 BAF 核小体重塑复合物的亚单位,可在生发中心调节 B 细胞命运,促进 PU.1 和 NF-kB 在细胞因子和 CD40 信号通路关键基因中的协作和序贯结合。而 ARID1A 突变则可使生发中心细胞向不...
Cancer Cell | 酶抑制剂增强淋巴瘤免疫治疗 威尔康奈尔医学院淋巴瘤研究人员的一项临床前研究结果表明,一种名为EZH2抑制剂的新型抗癌药物可能会大大增强某些癌症免疫疗法的效力。 肿瘤细胞中的EZH2酶活性被认为是许多癌症的重要因素。这项新报道的研究,包括在小鼠模型中的工作,发现将基于T细胞的免疫疗法与EZH2抑制相...
In article number 1801363 Shiladitya Sengupta, Ali Khademhosseini and co‐workers show organ‐on‐a‐chip systems can provide high‐throughput platforms for drug development, which could potentially bridge the gap between 2D cell culture and animal models. With recent breakthroughs in anticancer immunothe...
The addition of pembrolizumab to radiation did not improve survival in unresected, stage I or II non–small cell lung cancer. Generic Platinum Chemotherapy Shortages Did Not Increase Deaths January 3rd 2025 A national data analysis published by researchers from Penn Medicine reported that short-term...