The FDA has deemed the Antigenics Inc. (New York, NY) Oncophage late-stage investigational cancer vaccine an orphan drug for metastatic melanoma. The FDA orphan drug designation was designed to encourage the development of therapies for conditions affecting fewer than 200,000 people in the United ...
We present a stochastic network model of metastasis spread for de novo metastatic breast cancer, composed of tumor to metastasis (primary seeding) and metastasis to metastasis spread (secondary seeding), parameterized using the SEER (Surveillance, Epidemiology, and End Results) database. The model pr...
Among various cancers, patients whose primary cancers are hypoxic at diagnosis are more likely to have local recurrence and metastatic site recurrence, regardless of whether the initial treatment is surgery or radiation therapy. Cancer patients with conditions such as anemia or chronic obstructive pulmona...
Identification of metastatic prostate cancer was identified through targeted medical record review. Manual review of electronic medical records was performed for patients who met any of the following criteria: ICD-9 or ICD-10 codes for metastasis of the bone (198.5, C79.51, and C79.52) or maligna...
2023;6(10):e2337272. doi:10.1001/jamanetworkopen.2023.37272 related articles icon Related Articles Correction Error in Byline JAMA Network Open Key Points Question Is equal access to health care associated with reduced racial and ethnic disparities in the clinical outcomes of nonmetastatic castration-...
Hard, nodular liver: generally indicates metastatic disease to the liver. • Hemoccult-positive stools. • Ascites, lymphadenopathy, or pleural effusions: may indicate metastasis. ETIOLOGY Risk factors: • Chronic H. pylori gastritis. Gastric cancer develops in persons infected with H. pylori. ...
Tumor treatments based on induction of ferroptosis can be effectively applied to tumor cells that are resistant to apoptosis or chemotherapy. In addition, mesenchymal or metastatic cancer cells are highly sensitive to ferroptosis. For instance, the increased properties of epithelial mesenchymal transition ...
osimertinib (followed the accelerated-approval path as a breakthrough therapy with a single-arm design), and LOXO-101 (announced plans to submit data from the ongoing NAVIGATE Phase II trial for accelerated approval, enrolling patients with NTRK-fusion proteins across 14 metastatic solid tumors...
Immunotherapy, as a powerful strategy for cancer treatment, has achieved tremendous efficacy in clinical trials. Despite these advancements, there is much to do in terms of enhancing therapeutic benefits and decreasing the side effects of cancer immunoth
Cancers are a heterogeneous group of diseases and are generally classified using the WHO International Classification of Diseases for Oncology (ICD-O), which includes topography and morphology codes18. The diseases are further characterized along two main lines — histological and molecular characteristics...