New blood markers continue to be discovered, comprising RNA, DNA, and protein. On reviewing the literaturdoi:10.1007/s11888-015-0293-2Symonds, Erin L.Flinders Centre for Innovation in Cancer, Flinders University, University Drive, Bedford Park, South Australia, 5042, Australia;Bowel Health Service...
In order to distinguish SCC from other types of cancer, immunohistochemistry (IHC) is used as a valuable tool, confirming its squamous differentiation, and providing additional information about the tumor’s characteristics [50]. Specific markers are used to detect the expression of proteins that are...
MD. I was a technician in the Biological Markers program there. While there, I witnessed a lot of dishonesty and chicanery in the cancer research field. What still stands out, particularly, is that some of the contributing cancer research centers started looking into using the body’s immunity...
Surrogate end point: an outcome (eg, tumor size on a scan or a tumor marker blood test) that does not measure how a patient feels, functions, or survives, but is thought to predict clinical benefit. Despite its origins in HIV treatment, accelerated approval is now most common in oncology...
This study concludes, through scRNA-seq and T cell receptor sequencing profiling of immune cells from breast tumours and matched, blood, lymph node and normal breast tissue, that T cells exist in a state of continuous activation and that macrophages do not exist in distinct states of ...
However, by combining longitudinally indexed markers (including CA125), we show significant improvement in sensitivity and lead time over using CA125 alone. The sensitivity of the CA125 cut-off model used herein (71.4%, 95% CI 53.6–85.7) was similar to that reported previously using a ...
Differences were observed in all blood marker categories, from on-therapy until years post-chemotherapy. Associations were found between cognitive functioning and (1) blood markers (mainly inflammation-related) during, shortly-, or years post-chemotherapy and (2) white and gray matter metrics in ...
Tumor-specific DNA mutations, also known as circulating tumor DNA (ctDNA), can be detected in the cell-free component of peripheral blood samples in almost all patients with advanced colorectal cancer and many other advanced solid tumors.9 Several studies, including in colorectal cancer, have show...
in particular, enables the visual confirmation of protein expression and localization by fluorescent markers. In the conventional cytofluorimetry approach, isolation is achieved through the utilization of specific antibodies that recognize markers selected on CTCs. This method utilizes monoclonal antibodies spe...
At enrolment, participants provided information on a wide range of factors, physical measurements were taken, and biological samples (blood, urine and saliva) were collected for long-term storage. Participants have now been followed up for over a decade with more than 52,000 incident cancer cases...