2024年11月1日,中国海军医科大学丁劲,Wang Guang共同通讯在Cancer Communications在线发表题为“Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms”的研究综述,该综述提出了几种通过靶向中性粒细胞...
4. Li X, Wenes M, Romero P, Huang SC, Fendt SM, Ho PC. Navigating metabolic pathways to enhance antitumour immunity and immunotherapy. Nat Rev Clin Oncol 2019;16:425–41. 5. Mazumdar C, Dri...
The cDC1-driven cancer immunity cycle Para_01 DCs,特别是cDC1s,在所谓的‘癌症免疫循环’中起着核心作用,这一概念由Ira Mellman和Daniel S. Chen提出30,因为cDC1s对于启动和调节针对肿瘤的适应性免疫反应至关重要。 这个循环中的复杂且高度协调的一系列功能涉及由DCs介导的几个关键步骤,从最初巡逻组织以检测...
Rosenberg introduced interleukin (IL)-2 and tumor-infiltrating lymphocytes to the field of cancer immunology and immunotherapy. Tumor-infiltrating lymphocytes, lymphokine-activated killer cells, and cytokine-induced killer (CIK) cells were the cornerstones of this new pillar of cancer immunotherapy1...
thatusherinaneweraofcancerimmunotherapy(Hodietal.2010;Kantoffetal. 2010).These“first-into-class”treatmentsreflectthesubstantiveprogressthatbasic andtranslationalscientistshavemadetowardunderstandingthemechanismsunder- lyingprotectivetumorimmunityincancerpatients. ...
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish efficient and durable antitumour immunity. During priming, help signals are relayed from CD4+ T cells to CD8+ T cells...
研究小组2024年4月23日在《Molecular Cancer》上发表了题目为“Mutation of neurotrophic tyrosine receptor kinase can promote pan-cancer immunity and the efficacy of immunotherapy”的研究成果,其第一作者为福建医科大学附属泉州第一医院主任医师王聪仁。靶向...
Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy The immune response of immunotherapy in colorectal cancer remains low and new adjuvant targets are in demand. By in vivo CRISPR-Cas9 screening that targets membrane and secreted proteins genes, the authors identify...
Cancer Immunology, Immunotherapy is providing a timely and open access publication of original discovery and developments in basic and translational research ...
2024年4月12日,陆军军医大学叶丽林团队与合作者中国农业大学张国中团队、北京大学白凡团队及南京大学李颜团队在Nature Cancer杂志发表了题为An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy的研究论文,该研究系统地阐明了TBYS细胞的...