aSchematic representation of drug-atlas approach. If two cell lines have mutually exclusive sensitivity to either drug A or B, as shown by the intensity of each diamond, then two independent molecular mechanisms might be causal of this. However, when a third cell line is sensitive to both of...
In September 2022, the Accelerating Anticancer Agent Development and Validation workshop was held, focusing on global cancer drug development. Panelists discussed key barriers such as the lack of diagnostic services and human resources, drug accessibility and affordability, lack of research infrastructure...
Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading
eTable 1. Clinical Benefit of Drug-Indication Pairs Granted Accelerated Approval Between 2013 and 2017 That Have Been Converted to Regular Approval eTable 2. Examples of Indication Changes Between Accelerated and Regular Approval eTable 3. Indications of Oncology Drugs Receiving Accelerated After January...
Canadian Coordinating Office for Health Technology Assessment (CCOHTA). Metastatic melanoma vaccines. Emerging Drug List Issue 69. Ottawa, ON: CCOHTA; 2006. Chang AE, Aruga A, Cameron MJ, et al. Adoptive immunotherapy with vaccine-primed lymph node cells secondarily activated with anti-CD3 and ...
癌痛是癌症相关疼痛的简称,疼痛往往是因肿瘤直接造成,或是癌症相关的治疗带来的疼痛。癌痛会影响病人睡眠、饮食,严重者造成抑郁状态。合理正确的使用镇痛药物可以有效缓解疼痛,降低镇痛药带来的副作用。那么,癌痛病人应当如何正确服用镇痛药物呢?以下小知识是您需要了解的!
or enter the cancer cells. Additionally, the bacteria that coat cancer cells release DNA and various proteins that prevent the tumor from spreading [294,295]. To create naturally occurring nanowires that may be used as drug carriers for cancer treatment, Kumeria and colleagues [296] synthesized ...
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease characterized by a heterogeneous tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) constitute the major innate immune population in the TIME where they fac
While the increased screening, changes in lifestyle, and recent advances in treatment regimen have decreased colorectal cancer (CRC) mortality, metastatic disease and recurrence remains a major clinical challenge. In the era of precision medicine, the id
Cancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug therapy continue