Accurate prediction of cancer drug response is vital for guiding the design of anticancer drugs. In this study, we propose an end-to-end deep learning model named DeepAEG which is based on a complete-graph update mode to predict IC50. Specifically, we integrate an edge update mechanism on th...
Drug screening data from massive bulk gene expression databases can be analyzed to determine the optimal clinical application of cancer drugs. The growing amount of single-cell RNA sequencing (scRNA-seq) data also provides insights into improving therape
Among these, bortezomib is a proteasome inhibitor that induces ROS and ER stress in head and neck squamous cell carcinoma cells112, and celecoxib, a nonsteroidal anti-inflammatory drug, aggravates ER stress and induces apoptosis by altering the Bax/Bcl-2 ratio and increasing ROS in prostate ...
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease characterized by a heterogeneous tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) constitute the major innate immune population in the TIME where they fac
Patient Information: Breast Cancer Risk–Reducing Medications JAMA JAMA Patient Page July 21, 2020 This JAMA Patient Page describes the indications for use of medications to reduce breast cancer risk and the benefits and risks of the 2 major drug classes, SERMs (tamoxifen, raloxifene) and aromatas...
Curr. Cancer Drug Targets 2008, 8, 367–377. [Google Scholar] [CrossRef] Turner, H.E.; Harris, A.L.; Melmed, S.; Wass, J.A. Angiogenesis in endocrine tumors. Endocr. Rev. 2003, 24, 600–632. [Google Scholar] [CrossRef] [PubMed] [Green Version] Rubio, G.A.; Catanuto, P...
Drug repurposing is based on the research of new therapeutic indications of drugs approved for other pathologies. In this review, we explore GC and the different drugs repurposed for this disease. Keywords: gastric cancer; anticancer drugs; repurposing drugs 1. Introduction Gastric cancer (GC) ...
11 Currently, the only stool DNA test approved by the US Food and Drug Administration is a multitarget stool DNA test that also includes a FIT component, referred to as sDNA-FIT in this recommendation. When stool-based tests reveal abnormal results, follow-up with colonoscopy is needed for ...
• Provides an overview of the basic principles of cancer drug therapy. Subscriptions are $39.99 for one year. Your subscription will auto-renew annually at the end of each year-long term, unless cancelled. Payment will be charged to your iTunes Account at confirmation of purchase. The subsc...
Consequently, interrupting this PGE2-based dialog enhances the anti-tumoral drug-efficacy and mice survival as compared to Ara-C alone [142]. Cholesterol metabolism In cancer cells, modulation of intracellular cholesterol amount and distribution, by acting on LDL uptake, MVA pathway, cholesterol ...