In normal cells, hundreds of genes intricately control the process of cell division. Normal growth requires a balance between the activity of those genes that promote cell proliferation and those that suppress it. It also relies on the activities of genes that signal when damaged cells should unde...
Boxplots from the metabolite pentadecan-2-one, increased in all PCa cells when compared with PNT2 (normal cells), after univariate analysis, obtained at pH 7 and boxplots from the metabolite decanoic acid, increased in all PCa cells when compared with PNT2 (normal cells), after univariate ...
Comparison between both types of tumor cells and normal cells Of 90 probe sets differentially expressed between ductal carcinoma and both normal cells, and 106 probe sets dif- ferentially expressed between lobular carcinoma and both normal cells, only 25 probe sets were common (Table 3). ...
Evaluation of a RT-PCR based routine screening tool for the detection of disseminated epithelial cells in the bone marrow of breast cancer patients S. Becker, M. Banys, N. Krawczyk, S. Duerr-Stoerzer, ... T. Fehm Page 61 select article Screening for metastatic disease in newly diagnosed ...
Repetitive elements comprise at least 55% of the human genome with more recent estimates as high as two-thirds. Most of these elements are retrotransposons, DNA sequences that can insert copies of themselves into new genomic locations by a “copy and pas
There is no cellular selection in diapause; rather, every cell in the embryo reversibly enters the state, and when the environmental insult resolves, the embryo resumes normal development. We investigated whether cancer cells, and more specifically DTPs, enter an embryonic diapause-like state to ...
Full size table Processes putatively regulated by the HNRNPA2B1-regulated miRNAs in MCF-7 cells include TGFβ signaling (Fig. 5), which is protective in normal breast epithelium but acts as a tumor promoter after genetic and epigenetic changes involved in breast tumorigenesis accrue45. TGFβ indu...
In normal renal cells, pVHL (von Hippel-Lindau, a tumor suppressor protein, acting as an E3 ubiquitin ligase) binds to and degrades HIF (hypoxia inducible factor/hypoxia induced factor). However, at least in most ccRCC tumor cases, VHL/pVHL is mutated and loses its function and thus, ccRC...
Tumor-associated macrophage cells represent the predominant immune cell population in TME and exert pivotal roles in promoting tumor growth, angiogenesis, drug resistance and immunosuppression [119,120]. Recently, studies have found that IL-6 promotes normal macrophages to differentiate into M2 macrophages...
Transcriptional heterogeneity among malignant cells of a tumor has been studied in individual cancer types and shown to be organized into cancer cell states; however, it remains unclear to what extent these states span tumor types, constituting general features of cancer. Here, we perform a pan-ca...