Cancer metabolism refers to the alterations in cellular metabolism pathways that are evident in cancer cells compared with most normal tissue cells. Metabolic alterations in cancer cells are numerous and include
Furthermore, the mechanism by which ascorbate is selectively toxic to cancer cells versus normal cells is shown to involve alterations in redox-active iron metabolism mediated by mitochondrial O2⋅− and H2O2. As fundamental defects in oxidative metabolism leading to increased steady-state levels ...
Cancer cells are a kind of parasitic population of our own cells that resides in our body, utilizing the nutrition and supplementation of normal cells. They have learned to hijack the metabolic pathways and exploit the tissue microenvironment for their growth, sustenance, and progression. They have...
"Currently there's a real dearth of quantitative, chemically specific tools to be able to measure the changes that occur in tumor cells versus normal cells in response to drug treatment," said the senior author Hadley Sikes, an associate professor of chemical engineering at Massachusetts Institute ...
d, Comparison of predictions accuracies of liver cancer mutation density from features of normal liver cells versus cancer cells (HepG2). e, Mutation density in COLO829 melanoma cell line versus DHS density in COLO829, melanocytes, DHSs specific to COLO829 (not observed in melanocytes) and ...
Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple oncogenic pathways converge on induction of telomere attrition or telomerase overexpression and these eve
发现了以前未描述的高等级星形细胞瘤的预后亚类,这些亚类被认为类似于神经发生的阶段。显示神经细胞谱系标志物的一类肿瘤表现出较长的生存期,而两类富含神经干细胞标志物的肿瘤表现出同样较短的生存期。 预后不佳的亚类表现出增殖或血管生成和间充质的标志物。在复发时,肿瘤经常向间充质亚类转变。
Repetitive elements comprise at least 55% of the human genome with more recent estimates as high as two-thirds. Most of these elements are retrotransposons, DNA sequences that can insert copies of themselves into new genomic locations by a “copy and pas
Since their description and identification in leukemias and solid tumors, cancer stem cells (CSC) have been the subject of intensive research in translational oncology. Indeed, recent advances have led to the identification of CSC markers, CSC targets, a
2, in clonogenic growth assays, 1,25(OH)2D3 exhibited a substantial inhibition (ED50 = 0.25 – 1 nM) of the growth of these primary epithelial cells derived from the peripheral and central zones of normal prostate as well as from BPH and cancer. Interestingly, the growth inhibition was ...