Stem cells are not cancer cells but share certain growth properties with cancer cells. Cancer cells proliferate, some rapidly and some slowly, and most are partially differentiated. There are some, such as leuk
By adding an N-terminal α-helix to Cas12f, we created hpCasMINI, hpOsCas12f1, and hpAsCas12f1 variants that show improved gene activation and DNA cleavage in mammalian cells and mice. Shufeng Ma Kaitong Liao Zhili Rong ResearchOpen Access29 May 2025 Nature Communications Volume: 16, P:...
Cancer cells exhibit huge phenotypic plasticity, which can lead to adaptations to the tumour microenvironment and therapy. Much of this plasticity seems to be encoded in signal transduction networks, such that alterations in signalling dynamics can affec
Cancer is a complex and heterogeneous disease caused by cells deficient in growth regulation. Genetic and epigenetic changes in one or a group of cells disrupt normal function and result in autonomous, uncontrolled cell growth and proliferation.
The 340/380 ratios in one-minute were averaged and compared among control RSC-96 cells, RSC-96 cells co-cultured with DOK cells, and RSC-96 cells co-cultured with HSC-3 cells. To study whether cancer cells induce Ca2+ influx in normal RSC-96 cells, HSC-3 cell supernatant was collected...
cancer cells. Yang et al. created a completely artificial cancer vaccine (MPLA-Tn-KRN7000) using the Tn antigen, which is commonly found in cancer cells, along with the TLR4 ligand MPLA and the iNKT cell agonist KRN7000 to enhance its effectiveness. Comparative immunological research on wild-...
(that typically consist of thousands of millions of mixed cancer cells and normal cells) using bioinformatic approaches that determine the nature of and cellular prevalence of genotypes using features such as variant allele fraction, tumor purity and allele specific copy number information [32,39]. ...
Extracellular vesicles (EVs) with cell-like structures originate from various cells [1]. It has been proved that they play essential roles in cell-to-cell communication under different physiological and pathological conditions [2,3]. Based on the vesicle structure and the mechanism of intercellular...
More recently, a small study identified two CAF subtypes using only 26 single cells (17 CAF and 9 normal fibroblasts) and rely on the expression of a few marker genes, resulting in considerable classification uncertainty [36, 70]. Another recent study focused primarily on the myofibroblast compon...
Infiltrating FOXP3+ cells were detectable to a significantly higher extent within the tumor (4.0 ± 9.1 vs. 3.7 ± 14.4, p = 0.001) and in the stroma (4.2 ± 1.4 vs. 2.8 ± 6.1, p = 0.007) of ductal cancers as compared to lobular breast cancers (Figure 3). Figure 3 Box plot ...