T. et al. Direct activation of human resting T cells by IL 2: the role of an IL 2 receptor distinct from the Tac protein. J. Immunol. 139, 1550–1556 (1987). CAS PubMed Google Scholar Kelly, K. & Siebenlist, U. Mitogenic activation of normal T cells leads to increased ...
Despite standard treatment efforts, patients with glioblastoma (GBM), an aggressive form of brain cancer, inevitably succumb to recurrent disease. Integrative genomic analyses reveal that tumor cells hijack normal neurodevelopmental pathways to promote GBM growth and invasion. To target this pathway, we ...
Others interrupt the signals that prompt lung cancer cells to multiply, as shown in the image here. Immunotherapy works with your immune system to fight advanced cases of non-small-cell lung cancer. It doesn’t work for everyone, but when it does, the results look strong. You’d also get...
Boxplots from the metabolite pentadecan-2-one, increased in all PCa cells when compared with PNT2 (normal cells), after univariate analysis, obtained at pH 7 and boxplots from the metabolite decanoic acid, increased in all PCa cells when compared with PNT2 (normal cells), after univariate ...
1J and K). Additionally, AGD1 expression was higher in PCa cells compared to RWPE-1 cells, human normal prostate epithelial cell line (Fig. 1L). In summary, AGD1 was highly expressed in PC3/DU145-PCSCs and their exosomes, indicating that it may participate in CRPC progression. Fig. 1...
NTNG1 Modulates Cisplatin Resistance in Epithelial Ovarian Cancer Cells via the GAS6/AXL/Akt Pathway. Front Cell. Dev Biol. 2021;9:652325. Google Scholar Sho S, Court CM, Winograd P, Russell MM, Tomlinson JS. A prognostic mutation panel for predicting cancer recurrence in stages II and ...
(that typically consist of thousands of millions of mixed cancer cells and normal cells) using bioinformatic approaches that determine the nature of and cellular prevalence of genotypes using features such as variant allele fraction, tumor purity and allele specific copy number information [32,39]. ...
Repetitive elements comprise at least 55% of the human genome with more recent estimates as high as two-thirds. Most of these elements are retrotransposons, DNA sequences that can insert copies of themselves into new genomic locations by a “copy and pas
Through H1.0, Quisinostat inhibits cancer cell self-renewal and halts tumor maintenance without affecting normal stem cell function. Quisinostat also hinders expansion of cells surviving targeted therapy, independently of the cancer types and the resistance mechanism, and inhibits disease relapse in ...
Mutational signatures that correspond to those mutations that accumulate in normal somatic cells at a steady rate. Non-negative least squares (NNLS). A method for finding the optimal non-negative coefficients for a set of predefined vectors such that their weighted sum is as close as possible to...