How cancer cells are different Cancer cells are different to normal cells in several ways. These are some features of cancer cells They carry on reproducing They don't obey signals from other neighbouring cells They don't stick together They don't become specialised, but stay immature They don...
Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis. Tatiana Cañeque ,Leeroy Baron &Raphaël Rodriguez News & Views|30 April 2025 ...
T. et al. Direct activation of human resting T cells by IL 2: the role of an IL 2 receptor distinct from the Tac protein. J. Immunol. 139, 1550–1556 (1987). CAS PubMed Google Scholar Kelly, K. & Siebenlist, U. Mitogenic activation of normal T cells leads to increased ...
According to Dr. Donnenberg, the very fact that cancers can and do relapse after apparently successful therapy indicates the survival of a drug-resistant, tumor-initiating population of cells in many types of refractory cancers. “Because of the similarities between the way that normal stem cells ...
Normal somatic cells typically have finite cell division potential; telomere attrition is one mechanism to limit numbers of mitoses75. Cancers enlist multiple strategies to achieve replicative immortality. Overexpression of the telomerase gene, TERT, which maintains telomere lengths, is especially prevalent...
an operation can sometimes help. The surgeon may remove the part of the lung that has the tumor, or if necessary, the entire lung. Some people get radiation orchemotherapyafterward to kill any remaining cancer cells. Surgery usually doesn’t help with small-cell lung cancer because it probably...
Figure 1. Ascorbate Selectively Sensitizes NSCLC and GBM Cells, Compared with Normal Cells, to Chemo-Radiation In Vitro (A and B) Clonogenic survival post exposure of NSCLC cell lines H1299 and H292 and HBEpCs (A) or GBM cell lines U87 and U118 and NHAs (B) to increasing doses of ph...
To better investigate features, we obtained datasets with higher resolution annotations, i.e., BreCaHAD39 which provides nucleus-level tumor/normal annotations of 162 breast cancer ROIs (see the methods section for details), and 8 colorectal ROIs handannotated at nuclear resolution (>18,000 cells...
(that typically consist of thousands of millions of mixed cancer cells and normal cells) using bioinformatic approaches that determine the nature of and cellular prevalence of genotypes using features such as variant allele fraction, tumor purity and allele specific copy number information [32,39]. ...
Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage Despite being a hallmark of cancer, the identification of targetable vulnerabilities of aneuploid cancer cells remains limited. Here, the authors develop RPE1-hTERT cell lines with varying degrees of aneuploidy...