cells without smoking-related mutations after smoking cessation in the normal bronchial epithelium of ex-smokers39and epidemiological studies that have shown early smoking cessation substantially limits subsequ
The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single-cell profiling and demonstrate their strict control by the tumor genotype:
Repetitive elements comprise at least 55% of the human genome with more recent estimates as high as two-thirds. Most of these elements are retrotransposons, DNA sequences that can insert copies of themselves into new genomic locations by a “copy and pas
Figure 1. Ascorbate Selectively Sensitizes NSCLC and GBM Cells, Compared with Normal Cells, to Chemo-Radiation In Vitro (A and B) Clonogenic survival post exposure of NSCLC cell lines H1299 and H292 and HBEpCs (A) or GBM cell lines U87 and U118 and NHAs (B) to increasing doses of ph...
A549 and H4 cells were fixed with 4% paraformaldehyde solution in PBS (Santa Cruz Biotechnology, Dallas, Texas, USA) for 15 min, which was followed by the blocking procedure with 10% normal donkey serum (Sigma-Aldrich, Dorset, UK) for 30 min. After blocking, they were incubated with the...
Comparison between lobular carcinoma and normal cells Combined pairwise analysis and RP have identified 106 differentially expressed probe sets (84 named genes) com- mon to lobular carcinoma versus normal ductal and lob- ular cells. Of these probe sets, several genes encoding proteins involved in ...
Table 1 The isolation and detection techniques in liquid biopsy Full size table Biomarkers and detection methods Circulating tumour cells CTCs, which detach from the primary tumour, can enter the circulatory system and travel through the bloodstream. However, the majority of CTCs die in the periphera...
[31,32,33]. Anti-GRP 78 antibody can restore cancer cells to sensitivity to radiation therapy, which inhibits cell proliferation and enhances apoptosis, and has the advantage of targeting against cancer cells without affecting normal cells. Moreover, combination of anti-GRP 78 antibody and ...
To better investigate features, we obtained datasets with higher resolution annotations, i.e., BreCaHAD39 which provides nucleus-level tumor/normal annotations of 162 breast cancer ROIs (see the methods section for details), and 8 colorectal ROIs handannotated at nuclear resolution (>18,000 cells...
of PD-1, belongs to the B7 family and can be expressed not only by immune cells, such as T cells, B cells, macrophages, DCs, and mast cells, but also by normal tissue cells and aberrant tumor cells [42,43]. When PD-1 binds to PD-L1 on the surface of immune effector cells such...