It is widely accepted that cancerous cells are immortal and it is difficult to establish new cancer cell line. Evidence from experiments demonstrated that this difficulty has a genetic origin, as primary cancer cells did not completely lose their tumour suppressor pathways, which are expressed ...
The billions of cells that make up a tumour are descended from a single cell, in which disturbance of the genetic and epigenetic codes caused remodeling of the control circuits that governed that cell’s existence. A single damaging genetic or epigenetic event, however, is not enough to convert...
Zhang et al. showed that polyploid but not diploid ovarian cancer cells are resistant to hypoxia and accumulate the hypoxia-inducible factor HIF-1α, a key regulator of glycolysis. Individual polyploid tumour cells selected in this way are positive in sphere ...
proteins can transform and immortalise normal human breast epithelial cells [96]. High risk HPVs of the same type have been identified in benign breast tissues 1 to 11 years before the development of HPV positive breast cancers in the same women [145]. Transmission Sexual intercourse is regarde...
Co-culture or chimera models are characterized by the integration of two distinct cell types. These models are typically created by combining non-tumorigenic cells with cancer cells, enhancing complexity for two-cell type interactions, growth, and development. In one such systemic study, hybrid organ...
5D). These data indicate that PNPLA8 is crucial in maintaining the overall balance of ROS in TNBC cells, while mitochondrial ROS regulation may be subject to other mechanisms in addition to PNPLA8. As shown in Fig. 4G, PNPLA8 protein levels in breast cancer tissues are correlated with lymph...
Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes. Nat Commun. 2021;12(1):935. doi:10.1038/s41467-021-21245-w PubMedGoogle ScholarCrossref 14. Gong T, Jaratlerdsiri W, Jiang J, et al. Genome-wide ...
Curiously, in the non-tumourigenic PZHPV-7, amplification of EEF1A1 and EEF1A2 genes was detected, even though these cells that barely express EEF1A2 and EEF1A1 expression did not result to be higher than in cancer cells. This might be the consequence of cell immortalisation by ...
While the telomeres get shorter as cells age, and ultimately too short, the ends stick to one another, wreaking havoc when the cell divides and in most cases killing the cell. Because cancer cells never age, scientists theorized that they become immortalized by turning on production of telomeras...
differential response to HDAC inhibitors and to measure the selectivity of these drugs for cancer cells vs normal cells, we performed cell viability assays on a series of immortalised human bronchial epithelial cells (HBECs) that are non-tumourigenic (Ramirez et al, 2004; Sato et al, 2006)....