they are not recognized by a specific transcriptome (molecular signature) as is the case for embryonic stem cells (Sato et al., 2003). Thus tissue stem cells are defined as cells that are able to regenerate at clonal level (one cell only) a full tissue by producing its differentiated cellu...
The gut microbiome is a key player in the immunomodulatory and protumorigenic microenvironment during colorectal cancer (CRC), as different gut-derived bacteria can induce tumour growth. However, the crosstalk between the gut microbiome and the host in relation to tumour cell metabolism remains largely...
High heterogeneity and complex interactions of malignant cells in breast cancer has been recognized as a driver of cancer progression and therapeutic failure. However, complete understanding of common cancer cell states and their underlying driver factor
As these data were being generated, an enhanced AsCas12a (enAsCas12a) enzyme was reported to be compatible with CRISPR/AsCas12a libraries44, enabling replication of the initial pilot screens and expansion to a total of 16 cancer cell models. Notably, the replication of the initial screens ...
We also developed a user-friendly data portal to benefit the biomedical research community. Results Comprehensive characterization of the transcript landscape across over 1000 cancer cell lines To extensively dissect the transcriptional atlas across pan-cancer cell lines at the transcript level, reference-...
Experimental frame diagram Full size image VGG16 network is relatively simple and does not have so many hyperparameters. It is a simple network that only needs to focus on building a convolutional layer. First, a 3 × 3 filter with a stride of 1 is used to construct a convolutional ...
Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with a poor prognosis. B cells are crucial factors in tumor suppression, and tertiary lymphoid structures (TLSs) facilitate immune cell recruitment to the tumor microenvironment (TME). However, the function and mechanisms of tumor...
The ceRNA regulatory network based on MALAT1 plays an important role in the proliferation, metastasis, cell-cycle, and drug resistance of cancer cells [17]. Thus, MALAT1 represents a potential molecular biomarker for tumor diagnosis and molecular targeting applications Table 1. Table 1. Functional...
Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor cell-free DNA, molecular heterogeneity of cancer, and sample sizes that are not sufficient to reflect diverse patient populations. Here, we develop a cancer detection approach to address these challenges. It co...
a,bFlow cytometry analysis of CD44highLgr5+cell ratio in CD45-Epcam+tumor cells isolated from MC38-derived tumor nodules (a) in Supplementary Fig.2aor CT26-derived liver metastases (b) presented in Fig.2l,n = 4 biologically independent samples, Student’st-test.cSchematic diagram for ...