Background Despite the deleterious consequences of iron deficiency (ID) in patients with cancer, underdiagnosis is frequent. The CARENFER study aimed to assess the prevalence of ID using both serum ferritin concentration and transferrin coefficient saturation (iron-saturation of transferrin, TSAT) ...
Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J. Biol. Chem. 275, 21048–21054 (2000). Article CAS PubMed Google Scholar Peyssonnaux, C. et al. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J. ...
iron can contribute to both tumour initiation and tumour growth; recent work has also shown that iron has a role in the tumour microenvironment and in metastasis. Pathways of iron acquisition, efflux, storage
Methods One candidate is iron deficiency, as this is common in young women and a clinical feature of young age. In the present study, we used immuno-competent and immuno-deficient mouse xenograft models as well as hemoglobin as a marker of iron status in young BC patients to demonstrate ...
mic Cancer Patients Iron Deficiency and Anemia in Cancer Patients: The Role of Iron Treatment in Anemic Cancer PatientsIron Deficiency and Anemia in Cancer Patients: The Role of Iron Treatment in Anemic Cancer PatientsBehnaz AbiriMohammadreza Vafa...
Iron deficiency (ID) and anaemia are frequent complications in cancer patients, in particular during treatment with chemotherapeutic agents [1., 2., 3.]. ID, even in the absence of anaemia, may be associated with impaired physical function, weakness, and fatigue that can be ameliorated by iro...
J. and Alikhan, R. (2008), The use of intravenous iron in patients with cancer related anaemia: don’t overlook iron deficiency anaemia in colorectal cancer – response to Fitzgerald et al. British Journal of Haematology, 143: 755. doi: 10.1111/j.1365-2141.2008.07413.x Author Information ...
Table 3. Benefit-risk profiles of treatments for anaemia and ID in cancer patients Empty CellBenefitsRisks or limitations ESAs i.v. ironb RBC transfusions CRP, C-reactive protein; ESA, erythropoiesis-stimulating agent; Hb, haemoglobin; ID, iron deficiency; i.v., intravenous; PRCA, pure red ...
A European patient record study on diagnosis and treatment of chemotherapy-induced anaemia Purpose Patients with cancer frequently experience chemotherapy-induced anaemia (CIA) and iron deficiency. Erythropoiesis -stimulating agents (ESAs), iron... H Ludwig,M Aapro,C Bokemeyer,... - 《Supportive Car...
Previous studies6,7,8,9 had confirmed this theory and concluded that poorer prognosis of larger tumor was associated with tumor necrosis, iron deficiency anemia, tumor grade and a more aggressive underlying biology. In contrast, some studies10,11,12,15,16 reveled that patients with smaller tumor...