Iron supplementationCancerEpidemiologyPurpose Anemia is common in oncology and negatively impacts quality of life. However, there is lack of knowledge about iron deficiency (ID) epidemiology. The aim of this study was to prospectively assess iron status in patients with locally advanced or metastatic ...
infiltration of PD-1 + CD8 + T cells as a predictor of response to immunotherapy in pMMR cancers [19]. These findings indicate that in the context of GI tract cancers, which are highly heterogeneous, CD8 + T cells can be predictive markers for the efficacy of immunotherapy an...
Although some effective therapies have been available for cancer, it still poses a great threat to human health and life due to its drug resistance and low response in patients. Here, we develop a ferroptosis-based therapy by combining iron nanoparticles
By GO and KEGG functional enrichment analysis of DEGs, we found that in OSCC (oral squamous cell carcinoma) MDM4 is closely related to secondary metabolic process, cornified envelope and iron ion binding (Fig. 6A). Once the logFC values are considered, however, in BRCA the negative ...
specific prolyl hydroxylase-domain enzymes (PHDs) that initiate its degradation via the von Hippel–Lindau protein (pVHL) tumor suppressor protein.6 Under normoxia, PHDs hydroxylate two conserved proline residues (Pro 405 and 531) within HIF-2α, using oxygen, α-ketoglutarate and iron as ...
The treatment of genitourinary malignancies has dramatically evolved over recent years. Renal cell carcinoma, urothelial carcinoma of the bladder, and prostate adenocarcinoma are the most commonly encountered genitourinary malignancies and represent a he
Produced NO activated matrix metalloproteinases that degrade the extracellular matrix, enhancing the delivery and effectiveness of the BAGM nanozyme for synergistic PTT, starvation therapy, and NO gas therapy [101]. Li et al. described a multifunctional nanoparticle, GLDFe/Z-FA. This iron-doped MOF...
Cells possess many heme proteins, particularly in the transport of heme across membranes that is critical for iron absorption, the formation of hemoglobin and other hemoproteins, and iron recycling in macrophages. All of them were studied in detail by Raman spectroscopy and vibrational modes assignmen...
Taken together, these clinical outcomes support the role of FABP4 as a critical pro-inflammatory mediator that connects obesity with CVD in humans. In contrast to FABP4, FABP5 is highly expressed in the skin and least expressed in adipose tissue [231,254]. But FABP4 deficiency upregulates ...
c) identifying a Cancer Module selected from Tables 1-161 that is associated with therapeutic response or non-response of the subjects' cancer to the candidate drug or with toxicity to the candidate drug; and d) identifying the candidate drug as useful to treat cancer that is classified into ...