Life expectancy is usually into the teens. Mild/juvenile Canavan disease is characterized by mild developmental delay that can go unrecognized. Head circumference may be normal. The diagnosis of neonatal/infantile Canavan disease relies on demonstration of very high concentration of N-acetylaspartic ...
Hypotonia eventually changes to spasticity. Assistance with feeding becomes necessary. Life expectancy is usually into the teens. Mild/juvenile Canavan disease is characterized by mild developmental delay that can go unrecognized. Head circumference may be normal. 展开 年份: 2011 ...
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Life expectancy is usually into the teens. Mild/juvenile Canavan disease is characterized by mild developmental delay that can go unrecognized. Head circumference may be normal. DIAGNOSIS/TESTING: The diagnosis of neonatal/infantile Canavan disease relies on demonstration of very high concentration of N...
Gene replacement therapy is an attractive approach for this devastating disease, although the physiologic function of AspA and its metabolite N-acetylaspartate (NAA) is still not fully understood.We previously reported that systemic delivery of the human aspartoacylase (hAspA) gene by recombinant adeno...
Canavan's disease (CD) is a fatal autosomal recessive pediatric leukodystrophy in which patients show severe neurodegeneration and typically die by the age of 10, though life expectancy in patients...doi:10.1007/8904_2014_356Seemin S. Ahmed...
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