While this treatment is showing promise for patients with Canavan disease, it is still experimental and not approved as a treatment in the United States. In addition, there is not good natural history data on this disease. References Genetics Home Reference.Canavan Disease. Web. 24 December 2012...
Mutations in the gene for aspartoacylase (ASPA), which catalyzes deacetylation of N-acetyl-L-aspartate in the central nervous system (CNS), result in Canavan Disease, a fatal dysmyelinating disease. Consistent with its role in supplying acetate for myelin lipid synthesis, ASPA is thought to be...
J.B. Canavan, C. Scottà, A. Vossenkämper, R. Goldberg, M.J. Elder, I. Shoval, E. Marks, E. Stolarczyk, J.W. Lo, N. Powell, et al. Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn’s disease Gut, 65 (2016), pp. 584-594...
Homozygosity for mutation G212A of the gene for aspartoacylase is associated with atypical form of Canavan's disease. Clin Genet 2008;73:288-9.Velinov M, Zellers N, Styles J, et al. Homozygosity for mutation G212A of the gene for aspartoacylase is associated with atypical form of Canavan'...
Conditional associative learning is impaired in cerebellar disease in hu- mans. Behav. Neurosci. 108: 475-485, 1994.Canavan AG, Sprengelmeyer R, Diener HC, et al. Conditional associative learning is impaired in cerebellar disease in humans. Behav Neurosci 1994; 108: 1–11....
The MBP promoter is selective for oligodendrocytes in a mouse model of the leukodystrophy Canavan Disease.Georg, von Jonquieres
Johnson A. B., Kaul R., Casanova J., and Matalon R. (1989) As- partoacylase, the deficient enzyme in spongy degeneration (Canavan disease) is a myelin-associated enzyme. (Abstrt) J. Neuropathol. Exp.Neurol. 48, 349.Johnson A. B., Kaul R., Casanova J. and Matalon R. (1989...
Harris A. AhmadBristol Myers Squibb, Princeton, NJ;Arteid MemajBristol Myers Squibb, Princeton, NJ;Sarah HarrisBristol Myers Squibb, Princeton, NJ;James B. CanavanBristol Myers Squibb, Princeton, NJ;Wolters KluwerThe American Journal of Gastroenterology...
Current Trends and Novel ApplicationsCerebral Etiology and Treatment of the Gilles de la Tourette SyndromeCerebral Small Vessel Disease and Cognitive Impairment in Aging BrainCognition in InfantsCognitive AgingCognitive Dysfunction in Down SyndromeCognitive Neuroscience of Cross-Language Interaction in Bilinguals...
According to the European Center for Disease Control (ECDC), CRAB has been identified as one of the 10 most frequently isolated microorganisms in ICU-acquired healthcare-associated infections (HAIs), accounting for 14.7% of pneumonia episodes, 8.1% of bloodstream infection (BSI), and for 7.1% ...