In the present study, we show that vascular endothelial cells are the primary cellular target of sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor (s-HBEGF) mediates the crosstalk between vascular endothelial cells and keratinocytes. Mechanistically, s-HBEGF released from ...
Ovarian cancers, including those with PD-L1 positivity, exhibit a pattern of subclonal loss of MHC class I expression. This observation suggests a potential convergence of immune evasion pathways, making it essential to examine MHC class I status in PD-L1-positive tumors to unveil further immune...
After termination of the reaction with 1 m Tris, pH 7.5, the cells were solubilized as described above, and the cross-linked material was separated on SDS-PAGE and visualized by autoradiography (27). Displacement of HUVEC-bound 125I-endorepellin was performed by incubating confluent HUVECs (...
no patient had a blood pH lower than 7.4, which seems to be a critical point for both BK release20and, from our in vitro experiments, for NOS activation. Since the electronegative charge of membranes could be a major factor in BK activation, heparin (highly negatively charged molecule)29was...
The ability of nanoparticles (NPs) to be promptly uptaken by the cells makes them both dangerous and useful to human health. It was recently postulated that some NPs might cross the plasma membrane also by a non-endocytotic pathway gaining access to the