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Damage to cells by UVA is thought to involve ROS, including singlet O2, superoxide and hydroxyl radicals, and hydrogen peroxide. Some of the major harmful effects are DNA damage, systemic immune suppression, and accelerated aging (Didier et al., 2001). When thymic lymphocytes were exposed to ...
In three new studies, researchers found thathydrogenperoxide, theactive ingredientin over-the-counter whitening strips, can damage the protein-rich dentin tissue found beneath the tooth's protective enamel. Undergraduates working in the laboratory of Kelly Keenan, Ph.D., associate professor of chemist...
5. Melatonin protects the mitochondria function through its potent antioxidant activities and increases the efficacy of mitochondrial electron transport chain and reduces electron leakage. Through its potent antioxidative actions, it prevents tissue damage and blocks transcriptional factors of proinflammatory cyt...
The bound MPO also retains its enzymic functions and effectively interacts with hydrogen peroxide to mediate detachment of endothelial cells from their substratum. EC bound MPO-anti-MPO complexes can contribute to the complement-dependent EC injury demonstrated by some P-ANCA sera....
Endogenous peroxidase activity was blocked with hydrogen peroxide and antigen retrieval was achieved using 1 mM EDTA for γH2A.X, 10 mM sodium citrate buffer, pH 6.0 for active caspase 3 and BrdU and 0.0005% Trypsin for 20 min at 37 °C and PCNA. Tissue was blocked using an Avidin/Biotin...
we treated uninfected HbAA erythrocytes for 60 min with 1 mM hydrogen peroxide (H2O2) or 1 mM tert-butyl hydroperoxide (tBOOH)34,35. Cells were subsequently washed in buffer containing equimolar concentrations of dithiothreitol (1 mM dithiothreitol (DTT)) to restore reducing conditions an...
Senescence DNA damage Palmitate Nitrate Oleic acid 1. Introduction Ageing and obesity are two important health risks for people worldwide. Overfeeding results in storage of excess energy as triglyceride lipid droplets in adipocytes of white adipose tissue (Laviola et al., 2006). Hypertrophic adipocyt...
Even if several redox events may be involved in this signaling [3], it is known that the signaling is typically coupled to a stimulation of NADPH oxidase (NOX) activity triggering formation of hydrogen peroxide (H2O2), entering cells through specific aquaporins (also called peroxiporins), ...