Fatal familial insomnia (FFI) is a rare prion disease with autosomal dominant inheritance. Currently, there is only one published case study of FFI in Australia. FFI is universally fatal, with the disease duration ranging from 8 to 72 months. Clinically, it manifests with disordered sleep–wake...
The prevalent forms of ALS are sporadic (90%), while familial forms (10%) are mostly caused by mutations in genes encoding superoxide dismutase-1 (SOD-1), TAR-DNA binding protein-43 (TDP-43), fused in sarcoma (FUS), and C9orf72, even though mutations in numerous other genes have ...