Chemically active metabolites can cause toxicity either by direct extension of the properties of the mother compound, or are dependent on the pharmacology of the metabolite itself. They are therefore called reactive metabolites. Damage may be widespread or cell-specific. Cell death may be affected by...
FlnA localization within the cell was found to be regulated by inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP), which encodes IKAP (ELP1), a protein associated with familial dysautonomia (FD), with defective neuronal development and maintena...
andhere), andadvised changesto the "Warnings & Precaution" sections of the GnRHa label for male use -adding "the risk of diabetes, heart attack, sudden cardiac death, and stroke". ThisFDAsafety review identified there are "no known comparable studiesthat have evaluated the...
2020. She's had not only brain fog and fatigue but a racing heartbeat even when resting, elevated blood pressure and palpitations. The 49-year-old started seeing a cardiologist in late 2020 at a long COVID clinic and was diagnosed with dysautonomia, a malfunction of the autonomic nervous ...