adenosine triphosphatase (ATPase)a term used to refer to the enzymatic activity of certain intercellular processes that split ATP to form ADP and inorganic phosphate, when the energy released is not used for the synthesis of chemical compounds. Examples are the splitting of ATP in muscle contraction...
Sharma RK (1995) Signal transduction: regulation of cAMP concentration in cardiac muscle by calmodulin-dependent cyclic nucleotide phosphodiesterase. Mol Cell Biochem 149–150:241–247Sharma R. K. (1995) Signal transduction: regulation of cAMP concen- tration in cardiac muscle by calmodulin-dependent ...
POPDC proteins are three-pass transmembrane proteins with high affinity to bind cAMP [68]. The Popeye domain of POPDC is supposed to undergo a conformational change upon cAMP binding. POPDC are important players in cardiac and skeletal muscle physiology. POPDC1 (also called BVES) serves as an...
Expression of targeted CUTie in cardiac myocytes Figure 2: Targeting of CUTie to cardiac myocyte subcellular sites. Full size image Differential local [cAMP] during β-AR activation Figure 3: Differential regulation of the cAMP signal at different β-adrenergic targets. ...
Genetic manipulation and functional analysis of cAMP signalling in cardiac muscle: implications for a new target of pharmacotherapy: Figure 1 Ishikawa,Y.,Iwatsubo,... - 《Biochm.soc.trans》 被引量: 0发表: 2005年 Variation in Lignin Content and Composition (Mechanisms of Control and Implications...
Compartmentation of G protein-coupled signaling pathways in cardiac myocytes Annu. Rev. Pharmacol. Toxicol., 41 (2001), pp. 751-773, 10.1146/annurev.pharmtox.41.1.751 Google Scholar [13] S. Papa, A.M. Sardanelli, S. Scacco, Z. Technikova-Dobrova cAMP-dependent protein kinase and phospho...
… He signed in March 2019, has already collected $29 million, and won’t play his third game for the team until September 2021. By then, he’ll be 29 years old and coming off what’ll amount to a two-year layoff. Is it the Jets’ fault he suffered a serious core-muscle injury...
Peng Hongmei[18]等在进行体外培养实验时,采用的细胞是人胚胎心脏成纤维细胞(human fetal cardiac fibroblasts, HCFs),而诱导刺激HCFs则使用SiO2(200ng/ml),在给予刺激后,细胞质内的α-SMA呈现出显著的、表达阳性的肌丝结构,胚胎型平滑肌肌球蛋白(embryonic isoform of smooth muscle myosin, SMemb)的表现与之相似...
in a variety of cells, including cardiac myocytes, the intracellular concentration of cAMP in unstimulated conditions is around 1 μM6,7,8,9. However, the EC50of cAMP binding to the regulatory subunit of PKA has been reported to be in the 100–300 nM range10,11. Based on these values...
Agonist activation of the small GTPase, RhoA, and its effector Rho kinase leads to down-regulation of smooth muscle (SM) myosin light chain phosphatase activity, an increase in myosin light chain (RLC20) phosphorylation and force. Cyclic nucleotides can reverse this process. We report a new ...