Calcium is a crucialmicronutrientfor the human body. Extracellular calcium ions stimulate the calcification of bone matrix and cartilage, whileintracellular calciumions impactprotein synthesis,enzyme activity, and metabolic reactions. When cells are stimulated by various factors, thecalcium signalingpathwa...
However, these compounds can be turned fungicidal and actively kill fungal cells by the simultaneous pharmacological inhibition of calcineurin in the Ca -signaling pathway. However, calcineurin is crucial for the activation of the human immune response, so combinatorial drug therapy carries too much ...
It was demonstrated that Ca2+ signaling pathway involving calcineurin regulates IL-8 gene expression through activation of a transcription factor, NF-κB. 展开 关键词: interleukin-8 NF-&kappa B calcineurin calcium TNF-&alpha DOI: 10.1359/JBMR.0301256 被引量: 47 年份: 2004 收藏 引用 批量...
Moreover, we provided evidence for a Ca2+-regulated cancer cell signaling pathway and that the Ca2+ channel is a target of cancer cells. 展开 关键词: TRPV6 Numb Protein–protein interaction Calcium DOI: 10.1016/j.ceca.2012.10.005 年份: 2013 ...
components of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targets:的钙调神经磷酸酶信号通路在真菌细胞及其抗真菌的目标潜在成分.pdf 2015-11-12上传 components of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targets...
网络钙离子信号通道 网络释义 1. 钙离子信号通道 钙离子信号通道(Calcium signaling pathway) 基因表达谱PCR芯片介绍 返回 产品简介 基因列表 价格 产品简介 楚天生物钙离子 … www.sosoplus.com|基于2个网页
and described anti-C. albicans activity of inhibitors of this signaling pathway. We believe that targeting the calcium-calcineurin signaling pathway is a promising strategy to cope with C. albicans infection. 1. Introduction Candida albicans, an opportunistic human fungal pathogen (Cannon et al., 20...
parathyroid, kidney, heart, bone, brain, and skin7. CaSR activated by extracellular Ca2+(Ca2+ex) triggers multiple intracellular signaling pathways transduced through heterotrimeric G proteins; Gq/11, Gi/o, G12/13, and Gs3,8,9,10,11(Fig.S1). Thereof, the CaSR-mediated Ca2+signaling ...
Additionally, we sought to investigate the functional mechanisms of a clinically associated polymorphism found within this pathway. Blood pressure (BP) response to atenolol and hydrochlorothiazide was evaluated relative to genetic variation among Ca2+ signaling pathway candidate genes among uncomplicated ...
Nebivolol Induces Calcium-Independent Signaling in Endothelial Cells by a Possible β-Adrenergic Pathway 来自 LWW Journals 喜欢 0 阅读量: 23 作者: Gosgnach, Willy,Boixel, Cristophe,Névo, Nathalie,Poiraud, Thierry,Michel, Jean-Baptiste 展开 摘要: Nebivolol is a highly selective beta1-...