PI3K/mTOR, and Hippo pathway51. In this research, we focused on the RhoA/ROCK1 pathway and cytoskeletal regulation. Studies on the role of actin and its interacting partners have highlighted key signaling pathways, RhoA/ROCK and its downstream effector proteins that, through...
This CaSR mediated crosstalk between the extra- and intra- cellular Ca2+signaling is integral to protein biosynthesis and trafficking, including regulation of CaSR abundance, as well as inducing its active conformation and dictating its dynamic life cycle15. Prolonged exposure to Ca2+exis known to ...
Therefore, we obtained the sodium/calcium exchanger (termed NCX) proteins from the KEGG Database. The ncx gene of A. cristatus was cloned and characterized. The full length of ncx gene is 3055?bp, including a 2994‐bp open reading frame encoding 994 amino acids. The expression levels of...
The anti-inflammation mechanism of CMPA. (a) The boxplot data of different groups. (b) PCA results of the LPS and CMPA groups. (c) Volcano plots of DEGs in RAW264.7 cells with various treatments. (d) GO analysis of the down-regulated DEGs in the top 30. (e) KEGG pathways enrichment...
Utilizing string software, various biological and KEGG pathways were identified. Fos, Fosb, and Junb were predicted to be involved in cellular response to calcium ion and IL-17 signaling pathways. Furthermore, Fos and Socs3 were implicated in the IL-6 signaling pathway (Fig. 9C). Moreover, ...
Among top pathways identified by KEGG analysis were ECM-receptor interaction, Hippo signaling, protein digestion and absorption, PI3K-Akt signaling pathway, Wnt signaling pathway, cell cycle, TGF-beta signaling pathway, cellular senescence, and gap junction (Fig. 4D). Changes in Wnt and PI3K-Akt ...
Group comparisons, correlations and associations were performed using SPSS statistical software and two tailed Mann-Whitney U-tests. A P-value less than 0.05 was considered statistically significant. Pathway enrichment analyses were based on KEGG pathways (Partek Genome Suite v6.4)....
(Fig.1). These DEGs indicated that peanut kernels and shells showed different responses to Ca2+during pod development. During peanut pod development, calcium deficiency caused many genes to change in their expression level both in kernels and shells. Based on GO and KEGG pathway analyses, DEGs ...
To further deciphering the related signaling pathway of TMS, the regulated 153 proteins were inputted into Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database for bioinformatics analysis. Interestingly, as shown in Fig. 2d, twenty-two proteins were involved in key core mechanistic target...
Through the KEGG pathway analysis of differential lipids, we further verified that these lipids are mainly involved in glyceride and glycerophospholipid metabolic pathways. The increase of glycerides, especially MG and TG, may reflect the accumulation of intermediate products during lipolysis and the ...