The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease. Biochim Biophys Acta 2015;1849: 979-86. https://doi.org/10.1016/j.bbagrm.2015.05.009.Volk A,Crispino JD.The role of the chromatin assembly complex(CAF-1)and its p60 subunit(...
同时,有研究显示,CAF-1通过调控异染色质形成、信号转导和转录,在包括果蝇在内的多细胞生物的发育过程中发挥着关键作用[18]。 研究酵母体内的CAF-1相关亚基发现,由亚基CAC1(chromatin assembly complex 1)、CAC2和CAC3组成酵母体内的CAF-1[19]。在酵母中,CAF-1亚基的缺失不会导致个体致死,但会导致转录沉默发生异...
Nucleosome assembly by a complex CAF-1 and acetylated histones H3/H4. Focuses on the function of the chromatin assembly factor 1 (CAF-1) in nucleoprotein replication. Histone types bound by the factor in human and yeast cells... Verreault,Alain,Kaufman,... - 《Cell》 被引量: 762发表: 19...
More and more studies have analyzed the structure and biological function of the CAF-1 complex,and found that CAF-1 plays an important role in the process of somatic cell reprogramming. Therefore , this paper focuses on the structure , biologicalfunctionandtheroleofCAF-1insomaticce l ...
During the course of purification of the chromatin assembly complex, we monitored the abundance of the three CAF-1 subunits before and after immunoaffinity purification. Surprisingly, although a monoclonal antibody against p150 routinely immunodepleted most of CAF-1 p150 and p60, this antibody depleted...
loss of CAF-1 enhances transcription factor-driven reprogramming of somatic cells to pluripotent stem cells and direct lineage conversion of pre-B cells into macrophages and that of fibroblasts into neurons. Given the effect of the CAF-1 complex on chromatin accessibility in these and other cellular...
Strikingly, depletion of CHAF1A (the largest subunit of the CAF-1 complex, also known as p150) fully restored fork stability to HeLa-BRCA2KO as well as to RPE1-p53KOBRCA1KO cells, while causing fork degradation in their respective BRCA-proficient counterparts (Fig. 1a, b; Supplementary ...
英文名称: CNOT7 (CCR4-NOT Transcription Complex, Subunit 7, CAF1, hCAF-1) (MaxLight 405) 英文同义词: CNOT7 (CCR4-NOT Transcription Complex, Subunit 7, CAF1, hCAF-1) (MaxLight 405) CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按...
Cell Cycle Regulation of Human CDC6 Protein INTRACELLULAR LOCALIZATION, INTERACTION WITH THE HUMAN MCM COMPLEX, AND CDC2 KINASE-MEDIATED HYPERPHOSPHORYLATION The binding of mammalian MCM complexes to chromatin is cell cycle-regulated and under CDC2 kinase negative control. Here, we investigated the proper...
Or do you think that an artist's plans and motivations for their work affect its meaning? 抑或,你认为艺术家的创作动机影响着其作品的含义? Artistic interpretation is a complex web that will probably never offer a definitive answer. 艺术解读是个...