(2015). The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease. Biochim Biophys Acta 1849, 979-86.Volk,A. and Crispino,J.D. (2015) The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis...
Given the effect of the CAF-1 complex on chromatin accessibility in these and other cellular paradigms14,15,16, CAF-1 has been viewed as a general stabilizer of cell identity that prevents cells from adopting an open chromatin state characteristic of immature cells. However, studies of CAF-1 ...
More and more studies have analyzed the structure and biological function of the CAF-1 complex,and found that CAF-1 plays an important role in the process of somatic cell reprogramming. Therefore , this paper focuses on the structure , biologicalfunctionandtheroleofCAF-1insomaticce l ...
Nonetheless, the direct contribution of this subunit to histone binding in the context of the full CAF-1 complex has not yet been tested. In cells, histones are handed off to CAF-1 by the histone chaperone ASF1, which directly interacts with the C-terminal region of the CAF-1 middle ...
MW: 105223 Background: Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro 发表文章 SPECIES APPLICATION TITLE See more citationsABOUT...
This complex promotes histone H3-H4 deposition onto newly synthesised DNA in vitro. In metazoans, the depletion of its large subunit leads to the rapid accumulation of cells in S-phase. However, whether this slower S-phase progression results from the activation of cell cycle checkpoints or ...
CNOT7 (CCR4-NOT Transcription Complex, Subunit 7, CAF1, hCAF-1) (MaxLight 405) 中文名: 中文别名: CBNumber: CB04929732 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 CNOT7 (CCR4-NOT Transcription Complex, Subunit 7, CAF1, hCAF-1) (MaxLight 405)化学性质 ...
Here, we characterize the role of the plant orthologs HISTONE REGULATOR A (HIRA), UBINUCLEIN (UBN) and CAlcineurin BINding protein 1 (CABIN1) constituting the HIR complex. Arabidopsis loss-of-function mutants for the different subunits of the complex are viable but present reduced fertility in ...
同时,有研究显示,CAF-1通过调控异染色质形成、信号转导和转录,在包括果蝇在内的多细胞生物的发育过程中发挥着关键作用[18]。 研究酵母体内的CAF-1相关亚基发现,由亚基CAC1(chromatin assembly complex 1)、CAC2和CAC3组成酵母体内的CAF-1[19]。在酵母中,CAF-1亚基的缺失不会导致个体致死,但会导致转录沉默发生异...
Chromatin assembly factor-1 (CAF-1) is a multisubunit protein complex that comprises three polypeptide subunits known as p150, p60 and p48. CAF-1 is a nucleosome assembly factor that deposits newly synthesized and acetylated Histones H3/H4 into nascent chromatin during DNA replication. The p150 ...