regulatory T cells or tumor-associated macrophages has been observed in many cancers. Cell adhesions facilitate leukocyte recruitment through selectin- and integrin-mediated interactions that influence also the adaptive immunity. Infiltration ofCD8positive T cells preferentially happens in the periphery of tu...
Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your personal data. Manage preferences for further information and to change your choices. Accept all cookies ...
We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with...
Regarding the identity of these proteins, some members of the immunoglobulin, integrin, and the selectin superfamilies have been found to be expressed in the gonads and gametes, and have been shown to participate in gamete production and interaction during fertilization. Table 1 presents some ...
matrix via the basement membrane through the action of integrin expressed on the cell membranes of the endothelial cells (NPL 1). Furthermore, it is known that adhesion molecules such as integrin are also expressed by fibroblasts and fibroblasts also interact with the extracellular matrix (NPL 2)...
(the mode of action of statins) does not occur. As a result of the inhibition of the intracellular synthesis also the uptake of LDL in the blood fails in ApoE−/−and LDLR−/−mice. Thus, no changes in blood lipid levels are found in ApoE−/−and LDLR−/−mice upon ...
In contrast, the loss of E-cadherin expression is uncoupled from RECK-upregulation in carcinoma-derived cell lines (MCF7, MDA-MB-231, and A549). When RECK was artificially expressed in A549 cells, it showed little effect on EMT but elevated the level of integrin a5 and attenuated cell ...
Drug Research, Leiden University, PO Box 9502, NL-2300 RA Leiden, The Netherlands Using genome-wide expression profiling of a panel of 27 human mammary cell lines with different mechanisms of E-cadherin inactivation, we evaluated the relationship between E-cadherin status and gene expression levels...
allowing it to function in cell–cell adhesion as well as in the regulation of cell–substrate interactions. Pg performs these functions through regulation ofRNAand protein levels of a variety ofextracellular matrixproteins, theirintegrin receptors, and other cell–substrate adhesion-related molecules. ...
Basally, they express integrins (e.g., integrin α7β1) that bind laminins present in the basal lamina, and this interaction is important for maintenance of SC quiescence (Rozo et al., 2016). Apically, M-cadherin (Mcad) (encoded by Cdh15) contributes to adhesive interactions with the ...