An example of such cross talk between cadherin and integrin receptors has been demonstrated in keratinocytes, where cadherins downregulate integrin expression during keratinocyte differentiation (=-=Hodivala and Watt, 1994-=-). It is likely that integrin expression also alters cadherin expression or ...
Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can lead to sensory and motor dysfunction, which seriously affects patients' quality of life and imposes a major economic burden on society. The pathological process of SCI is divided into primary and se...
Cadherin-like proteins are widely accepted as functional Cry toxin receptors. Contrary to the generally observed localization for cadherin proteins to regions of cell–cell interaction, cadherin proteins binding Cry toxins localize mostly to the brush border membrane of midgut cells (Chen et al., 2005...
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1d. Abbreviations: Grik2, glutamate receptor ionotropic, kainate 2; mGluR, metabotropic glutamate receptor; nAChRs, nicotinic acetylcholine receptors; Tuba, tubulin alpha chain; Tubb, tubulin beta chain; FT, cadherin-related tumor suppressor; STS, steryl-sulfatase; SPR, sex peptide receptor; Tmem2,...
VE-cadherin is an endothelial cell-specific-homo-dimeric adhesion molecule that facilitates the formation of cell/cell adherent junctions [79]. VE-cadherin is upregulated and the human VE-cadherin promoter region is highly activated during tumor angiogenesis [80]. Experimentally, several decoy VE-cad...
An example of widely studied glycoproteins are haptoglobins (Hp), a hemoglobin-binding glycoprotein secreted by the liver (Fig.1b). As a positive acute-phase response protein and the ninth most abundant protein in blood, Hp plays an important role in different biological processes. Hp’s primar...
De novo pathogenic variants in N-cadherin cause a syndromic neurodevelopmental disorder with corpus collosum, axon, cardiac, ocular, and genital defects. Am J Hum Genet. 2019;105(4):854-868. doi:10.1016/j.ajhg.2019.09.005PubMedGoogle Scholar 45. Lam M, Chen CY, Li Z, ...
R. Cadherins interact with synaptic organizers to promote synaptic differentiation. Front. Mol. Neurosci. 11, 142 (2018). Article PubMed PubMed Central Google Scholar Michibata, H. et al. Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse ...
In terms of GO functions, the high-risk group mainly focused on mitosis, epithelial polarization, protein regulation, desmosome, cadherin, etc. The low-risk group focused on adaptive immune response, B cell receptor signal transduction, lipid metabolism, immune-related T cell activity, T cell ...