We found that CatC aggravates neuroinflammation by promoting MG polarization towards M1 phenotype, and this effect is mainly achieved through activation of Ca2+-dependent PKC/p38 MAPK/NF-κB pathway which is triggered by glutamate receptor subunit NR2B. Our study may have implications for the ...
and p38 are crucial to the immunomodulatory effect of PCP. We further demonstrated that PCP-treated cells also exhibited increased the activity of PKC, mRNA and protein expression levels of p38 and NF-κB, which is also reduced with a Ca2...
Type-2 diabetic rat heart: The effect of kolaviron on mTOR-1, P70S60K, PKC-α, NF-kB, SOD-2, NRF-2, eNOS, AKT-1, ACE, and P38 MAPK gene expression profile. Biomed Pharmacother. 2022;148: 112736. Article CAS PubMed Google Scholar Wang X, et al. Isolation, purification and ...
影响神经系统信号级联 氧化还原信号(ROS和氧化状态)还调节转录因子(如NF-κB)、活化T细胞的核因子和活化蛋白1(AP-1)以及酪氨酸磷酸化蛋白PKC的氧化还原状态的功能。 研究人员观察到H2O2可增加皮质神经元和 PC12 细胞中 ERK 和 cAMP 反应元件结合蛋白 (CREB) 的磷酸化。 参与学习和记忆 ROS 在大脑的不同部位(如...
Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation Int. J. Biochem. Cell Biol., 38 (2006), pp. 2082-2091 View PDFView articleView in ScopusGoogle Scholar [110] S. Katz, R. Boland...
炎症因子的表达CCI模型组显著高于正常对照组,而京尼平苷组CCI大鼠炎症因子表达显著降低,而添加了 EGFR激动剂的京尼平苷组炎症因子表达明显.5.IHC和WB对组织中p53,p38和EGFR的表达水平进行检测,同时用蛋白免疫印迹检测组织中 EGFR/PI3K/AKT 通路相关的 ERK,p38,EGFR,IκB,p50,NF-κB,p65,PI3K,AKT等蛋白表达水平...
(e.g., actin, myosin, integrin, paxillin and tensin) in concerted actions that are regulated by various signalling molecules, including protein kinase C (PKC), mitogen-activated protein kinases [MAPK; c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38], Rho ...
Similarly to the lack of any effect of the PKC inhibitor on the activation of ERK1/2 and p38 MAPK, inhibiting PKC had no effect on NPS R-467-induced activation of this channel. Therefore, our data show that the CaR, acting via p38 MAPK, regulates a large-conductance CAKC in U87 ...
Y.D. Cui, O. Inanami, T. Yamamori, K. Niwa, H. Nagahata, M. Kuwabara, FMLP-induced formation of F-actin in HL60 cells is dependent on PI3-K but not on intracellular Ca2+, PKC, ERK or p38 MAPK, Inflamm. Res. 49 (2000) 684-691....
敲除 内源性p2)r5的表达能抑制LPA引起的脐静脉内皮细胞收缩,从而确认了p2y5 是一个功能性的LPA受体,并建议将该受体命名为LPA6 13010同年Lee等的研 究也表明P2Y5是一个LPA激活的G-蛋白偶联受体,其可与Gi和G12,13蛋白相 偶联,导致【Ca2+】j升高,ERKl/2磷酸化,而且该过程受P38 MAPK、P13K、PLC 和PKC调控...