This chapter provides an understanding of how a buffer will affect Ca2+ homeostasis within a cell and discusses the relevant parameters that need to be considered. Most studies dealing with EF-hand Ca2+ binding proteins focus either on their metal-binding affinities (KD values) or elucidate their...
Besides their proven Ca(2+) buffer function, some might additionally have Ca(2+) sensor functions. Ca(2+) buffers have to be viewed as one of the components implicated in the precise regulation of Ca(2+) signaling and Ca(2+) homeostasis. Each cell is equipped with proteins, including ...
Supporting Results, with Validation of the Linear Noise Approximation, [Ca 2+ ] Fluctuations in the Presence of Multiple Buffers, Influence of the Buffer Dissociation Constant κ on [Ca 2+ ] Fluctuations, Timescale of Domain [Ca 2+ ] Fluctuations, [Ca 2+ ] Fluctuations during a Time-...
In addition, the computations revealed that, despite its low Ca affinity, ATP acts as a significant buffer and carrier for Ca, even at the modest elevations of [Ca] reached during influx of Ca. 展开 关键词: CiteSeerX citations Spatiotemporal Features of Ca2+ Buffering and Diffusion in ...
Control experiments adding Ca2+buffer (CaB) instead of histamine showed no response in −∆/+∆TMRM and basal −∆/+∆TMRM ratio did not change by silencing either MICU1 or UCP2 compared to control cells (Fig.4c, d). Store-operated Ca2+entry (SOCE) after ER Ca2+depletion, whi...
Kevin KOhlemillerM CharlesLibermanThe Journal of neuroscience : the official journal of the Society for NeuroscienceTong B, Hornak AJ, Ste X, Maison F, Ohlemiller KK, Liberman MC (2016) Oncomodulin, an EF-hand Ca2ϩ buffer, is critical for maintaining co- chlear function in mice. J ...
These data suggest that mitochondria of BI-1-deficient B cells exceed their buffering capacity after a few hours in culture, and we envisaged that clamping the intracellular Ca2+ with the cell-permeable Ca2+ buffer BAPTA-AM should inhibit this Ca2+-dependent cell death. However, this ...
Author SummaryCalmodulin is a versatile Ca2+ signal mediator and a buffer in a wide variety of body organs including the heart and brain. In the brain, cal... Y Kubota,MN Waxham,EJ Crampin - 《Plos Computational Biology》 被引量: 37发表: 2010年 ...
Ca2+ fluxes around pollen grains and pollen tubes of Lily; Normal development and effects of thermal shock, BAPTA-type buffer microinjection and depletion ... AM et al. Ca 2+ fluxes around pollen grains and pollen tubes of lily; normal development and effect of temperature shock, BAPTA-type...
www.nature.com/scientificreports OPEN Mitochondrial Ca2+ uptake controls actin cytoskeleton dynamics during cell migration received: 23 May 2016 accepted: 14 October 2016 Published: 09 November 2016 Julien Prudent1,*, Nikolay Popgeorgiev2,*, Rudy Gadet2,*, Mathieu Deygas2, Ruth Rimok...