参考文献: 1.Tsukasa Iwakura, Kengo Kidokoro, Seiji Kishi, et al. Elucidation of the Molecular Mechanism of Albuminuria Improvement by Nonsteroidal Mineralocorticoid Receptor (MR) Antagonists Focusing on Podocyte Calcium (Ca2+...
Definitions Neuronal Ca 2+ dynamics are tightly controlled by endogenous calcium -binding proteins (CaBPs), which may bind one or more Ca 2+ ions either in a cooperative or noncooperative manner. The binding of Ca 2+ to buffers can be described kinetically by using binding and unbinding rate...
RIS photoactivation stopped muscular Ca2+-dynamics. a Maximum intensity projection of RCaMP imaging in BWM cells of an immobilized animal (arrow: pharynx, pmyo-2::mCherry marker). Boxed regions: Violet, blue: regions of interest for dorso-ventrally alternating activity; white: region of interest...
but very limited information is available about the effect of Ca2+signaling in DCM. In this review, we discuss the remodeling of subcellular organelles in DCM and how this remodeling potentially contributes to disruption in Ca2+dynamics/homeostasis. We also review the effect of inflammation and pote...
Therefore, using live fluorescence imaging, we performed the first examina- tion of Ca2+ dynamics in eggs from young and naturally-aged mice. Perhaps surprisingly we find that, in contrast to somatic cells, ble of mounting [aCnad2+r]eishpoomndeionsgtatsoisarnemapapinrosprreilaatteivCelay2+...
Hydration of the dTn.dAn x dTn parallel triple helix: a Fourier transform infrared and gravimetric study correlated with molecular dynamics simulations. We present a comparative analysis of the water organization around the dTn.dAn x dTn triple helix and the Watson-Crick double helix dTn.dAn respec...
Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics The ER plays a fundamental role in storing cellular Ca2+, generating Ca2+signals, and modulating Ca2+in both the cytosol and mitochondria. Genetically encoded Ca2+sensors can be explicitly ...
Rodriguez-Moreno, Calcium Dynamics and Synaptic Plasticity, Adv Exp Med Biol, 1131 (2020) 965-984. [5] J. Shan, A. Kushnir, M.J. Betzenhauser, S. Reiken, J. Li, S.E. Lehnart, N. Lindegger, M. Mongillo, P.J. Mohler, A.R. Marks, Phosphorylation of the ryanodine receptor ...
(1) While we provide strong evidence for the role of VGCCs as a contributor to alterations in NRXN1α+/− neurons, in this study, we employed the non-ratiometric calcium reporter Fluo-4 AM to represent intracellular calcium dynamics in the absence of ground-truth electrophysiological ...
(NA 1.4). A line scan of Ca2+dynamics was obtained with an Sp8 confocal microscope (Leica, USA) and a 63× oil objective (NA 1.4) at 35 ± 0.5 °C. To determine the effects of transient intracytoplasmic injection on SANPCs, glutamate or vehicle was injected via a glass ...