C5orf66-AS1胃癌甲基化转录因子背景:LncRNA是一种长度大于200个核苷酸的RNA,没有编码蛋白的阅读框,不能进一步翻译成为蛋白.目前研究表明LncRNA参与胃癌发生以及发展,有关LncRNA甲基化在胃癌中的作用和机制研究尚少.本组前期研究发现,LncRNA C5orf66-AS1在胃癌,尤其是早期胃癌的表达明显降低,其调控机制尚不清楚.目的...
Over-expression of C5orf66-AS1 promoted the proliferation of cervical cancer cells, while downregulation of C5orf66-AS1 promoted the apoptosis of cervical cancer cells. C5orf66-AS1 was identified as the sponge of miR-637 by RNA immunoprecipitation (RIP) and luciferase reporter assays. Exogenous ...
Xu, FenglouGuo, YanliShen, SupengLiang, JiaKuang, GangDong, ZhimingMolecular CarcinogenesisGuo W, Lv P, Liu S, Xu F, Guo Y, Shen S, Liang J, Kuang G and Dong Z: Aberrant methylation‑mediated downregulation of long noncoding RNA C5orf66‑AS1 promotes the development of gastric ...
methylationAs a long non-coding RNA, C5orf66-AS1 is located adoi:info:doi/10.1002/mc.22806GuoHebeiWeiHebeiPingHebeiLiuHebeiShengnanHebeiFenglouHebeiYanliHebeiShenHebeiSupengHebeiLiangHebeiMolecular CarcinogenesisGuo W, Dong Z, Shi Y, et al. Aberrant methylation-mediated down- regulation of ...
Intragenic DNA methylation of PITX1 and the adjacent long non-coding RNA C5orf66-AS1 are prognostic biomarkers in patients with head and neck squamous cell carcinomasPITX1 and C5orf66-AS1 methylation predicts survival in HNSCCdoi:10.1371/journal.pone.0192742Verena Sailer...