目的探讨3-oxo-C12-HSL对MH-S小鼠肺泡巨噬细胞自噬的影响.方法用LasI基因(3-oxo-C12-HSL合成基因)缺失型和野生型的铜绿假单胞菌(PA)菌株的培养物上清液以及化学合成的3-oxo-C12-HSL信号分子处理MH-S细胞,激光共聚焦荧光显微镜观察LC3-GFP荧光斑点以及Westernblot检测LC3Ⅱ/L
目的探讨3-oxo-C12-HSL对MH-S小鼠肺泡巨噬细胞自噬的影响.方法用Las I基因(3-oxo-C12-HSL合成基因)缺失型和野生型的铜绿假单胞菌(PA)菌株的培养物上清液以及化学合成的3-oxo-C12-HSL信号分子处理MH-S细胞,激光共聚焦荧光显微镜观察LC3-GFP荧光斑点以及Western blot检测LC3Ⅱ/LC3Ⅰ比值来监测自噬的形成,同时...
十二酰-DL-高丝氨酸内酯 (C12-HSL) 是一类高丝氨酸内酯,包括;N-庚酰-DL-高丝氨酸内酯 (C7HSL)、N-辛酰-高丝氨酸内酯 (N-C8-HSL)、N-癸酰-DL-高丝氨酸内酯 (N-C10-HSL)、N-(3-氧癸酰)高丝氨酸-L-内酯 (3-oxo-C10 HSL)、N-(3-氧十二酰)高丝氨酸-L-内酯 (3-oxo-C12-HSL)、N-(3-氧十四...
英文别名N-dodecanoyl-L-Homoserine lactone | C12-HSL | N-[(3S)-Tetrahydro-2-oxo-3-furanyl]dodecanamide | N-lauroyl-L-homoserine lactone 规格或纯度≥98%(HPLC) 英文名称Dodecanoyl-L-homoserine lactone 生化机理群体感应信号产生,N -十二酰基- L -高丝氨酸内酯是 N -酰基-高丝氨酸内酯家族的成员。 N...
We observed that 3-oxo-C12:2-HSL decreases expression of pro-inflammatory cytokines such as, Interleukine-1β (-3 %) and Tumor Necrosis Factor-α (TNFα) (40 %) by stimulated immune RAW264.7 cells and decreased TNF secretion by stimulated PBMC in a dose-dependent manner, between 25 μM...
Growth curves and 3-oxo-C12-HSL autoinducer concentrations in culture supernatants.Thilo KöhlerHajer OuertataniSakouhiPierre CossonChristian van Delden
aeruginosa associated 3-oxo-C 12 -HSL exerts the inhibitory effect on S. epidermidis growth and biofilms and thus it may also help Pseudomonas to dominate under the co-infection conditions.doi:10.1016/j.micpath.2017.08.009Singh, Pradeep Kumar...
aeruginosa signal molecule N-(3-oxo-dodecanoyl)-l-homoserine lactone (3-oxo-C12-HSL) has been reported to inhibit function of PPARs in mammalian cells. This suggests that binding of 3-oxo-C12-HSL to PPARs could increase inflammation during P. aeruginosa infection, particularly if it could ...
3-(oxododecanoyl)--homoserine lactone (3-o-C12-HSL) has the potential to modulate the immune system of its host. However, the mechanism of that activity is yet to be fully characterized. To be able to understand this activity, we determined whether 3-o-C12-HSL has a direct effect on ...
Thus, altered MUC3 expression caused by long-term attenuated ERK1/2 activity might correlate with the death of undifferentiated Caco-2 cells induced by 3-oxo-C12-HSL.Bioscience, Biotechnology, and BiochemistryShimizu H, Baba N, Nose T, Taguchi R, Tanaka S, Joe GH, Maseda H, Nomura N, ...