The presence of RELA as the fusion partner indicates a close association of aberrant NF-魏B activity with tumorigenesis. However, the oncogenic role of the C11orf95 has not been determined. Here, we performed ChIP-seq analyses to explore genomic regions bound by RELA FUS and H3K27ac proteins...
We here describe a case of a sarcoma developing in a patient previously treated with chemotherapy and radiation whose original ependymoma and recurrent sarcoma were both shown to carry the type 1 C11orf95–RELA fusion transcript indicating a monoclonal origin for both tumors. This is a preview of...
C11orf95-RELA fusion proteins translocated spontaneously to the nucleus to activate NF-κB target genes, and rapidly transformed neural stem cells-the cell of origin of ependymoma-to form these tumours in mice. Our data identify a highly recurrent genetic alteration of RELA in human cancer, and ...
Publisher Correction to: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formationdoi:10.1186/s40478-021-01157-yGENE expressionEPENDYMOMAEPIGENETICSEPIGENOMICSAn amendment to this paper has been published and can be access...
fusion genemouse modelThe majority of supratentorial ependymomas (ST-ependymomas) have few mutations but frequently display chromothripsis of chromosome 11q that generates a fusion between C11orf95 and RELA ( RELA FUS ). Neural stem cells transduced with RELA FUS exvivo form ependymomas when ...
Molecular genetic analysis revealed the presence of type 1 C11orf95:RELA fusion transcript. To date, 22 cases of ES have been reported in the literature, and only one case harbored type 1 C11orf95:RELA fusion transcript.doi:10.1111/neup.12770Swati Mahajan...
Nambirajan A, Malgulwar PB, Sharma MC, Singh A, Pathak P, Satyarthee GD, et al. : C11orf95-RELA fusion present in a primary intracranial extra- axial ependymoma: report of a case with literature review. Neuropa- thology 36 : 490-495, 2016...
Over 70% of supratentorial ependymoma are driven by an oncogenic fusion between C11orf95 and Rela (denoted CRFUS). CRFUS expression initiates ependymoma development in mice by potentially acting as an oncogenic transcription factor and disrupting gene expression programs. We hypothesized that specific ...
Since 2014, it has been known that an intrachromosomal fusion C11orf95-RELA is an oncogenic driver in ST-EPN [Parker et al. Nature 506:451-455 (2014); Pietsch et al. Acta Neuropathol 127:609-611 (2014)] but the molecular mechanisms of oncogenesis are unclear. Here we show that the...
C11orf95-LOC-RELANon-coding RNAp65/RELAEpendymoma (EPN) is the third most common central nervous system tumor in childhood. Recent advances in the molecular classification of EPN revealed a supratentorial (ST) ependymoma subgroup characterized by C11orf95-RELA fusion.We describe a novel RELA-...