C11orf95-RELASupratentorial ependymomaTranscription factor3D genomeSupratentorial ependymoma (ST-EPN) is a type of malignant brain tumor mainly seen in children. Since 2014, it has been known that an intrachromosomal fusion C11orf95-RELA is an oncogenic driver in ST-EPN [Parker et al. Nature ...
C11ORF95/RELA融合基因t(11;11)探针试剂(荧光原位杂交法)-探针-广州安必平医药科技股份有限公司(股票代码:688393)专注于肿瘤筛查与诊断,自主研发了一系列肿瘤筛查及诊断试剂与配套设备,主要应用科室为病理科。目前已搭建液基细胞学(LBP)、聚合酶链式反应(PCR)、
We here describe a case of a sarcoma developing in a patient previously treated with chemotherapy and radiation whose original ependymoma and recurrent sarcoma were both shown to carry the type 1 C11orf95–RELA fusion transcript indicating a monoclonal origin for both tumors. This is a preview of...
In each case, C11orf95-RELA fusions resulted from chromothripsis involving chromosome 11q13.1. C11orf95-RELA fusion proteins translocated spontaneously to the nucleus to activate NF-κB target genes, and rapidly transformed neural stem cells-the cell of origin of ependymoma-to form these tumours in...
C11orf95/RELA融合基因检测-分子病理-广州安必平医药科技股份有限公司(股票代码:688393)专注于肿瘤筛查与诊断,自主研发了一系列肿瘤筛查及诊断试剂与配套设备,主要应用科室为病理科。目前已搭建液基细胞学(LBP)、聚合酶链式反应(PCR)、免疫组织化学(IHC)和荧光原
C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma. Nature 2014;506:451-455.Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, et al. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. Nature 2014; 506(7489): 451-455. doi: 10.1038/...
Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dal- ton JD, Li Y et al (2014) C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma. Nature 506:451-455Parker M, Mohankumar KM, Punchihewa C, et al: C11orf95-RELA fusions drive oncogenic NF-kB signalling in ...
Nambirajan A, Malgulwar PB, Sharma MC, Singh A, Pathak P, Satyarthee GD, et al. : C11orf95-RELA fusion present in a primary intracranial extra- axial ependymoma: report of a case with literature review. Neuropa- thology 36 : 490-495, 2016...
C11orf95NF-κB signalingRCAS/tv-a systemRELAependymomafusion genemouse modelThe majority of supratentorial ependymomas (ST-ependymomas) have few mutations but frequently display chromothripsis of chromosome 11q that generates a fusion between C11orf95 and RELA ( RELA FUS ). Neural stem cells ...
Publisher Correction to: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formationdoi:10.1186/s40478-021-01157-yGENE expressionEPENDYMOMAEPIGENETICSEPIGENOMICSAn amendment to this paper has been published and can be access...