The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation. J Biol Chem 2012;287: 15996-6006.Ahmed, S. F., Deb, S., Paul, I., Chatterjee, A., Mandal,
Hsc70羧基末端反应蛋白2) carboxyl-terminal protease 羧基末端蛋白酶 1. Sequence alignment showed that GhCtp was highly homo-(logous) to a family of carboxyl-terminal proteases (Ctp) from other species. GhCtp蛋白与拟南芥和水稻中的一类羧基末端蛋白酶具有较高的同源性 ,在GhCtp的N 末端有 1个精...
There are comments on PubPeer for publication: Upregulation of C Terminus of Hsc70-Interacting Protein Attenuates Apoptosis and Procoagulant Activity and Facilitates Brain Repair After Traumatic Brain Injury (2020)
The U-box E3 ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein) binds Hsp90 and/or Hsp70 via its tetratricopeptide repeat (TPR), facilitating ubiquitination of the chaperone-bound client proteins. Mechanisms that regulate the activity of CHIP are, at present, poorly understood. We ...
Some of these examples include: the trimeric chaperone system of Hsc70, Hsp110 and J-protein which together disaggregate αSyn fibrils in an ATP-dependent manner14; the small molecule promethazine prevents the aggregation of human insulin and human lysozyme, and depolymerises preformed fibrils23; ...
Li F, Xie P, Fan Y, Zhang H, Zheng L, Gu D, Patterson C, Li H. C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1. J Biol Chem. 2009;284:20090 -20098....
Molecular biologyCellular biologyNeurobiology Role of C-terminus of Hsc70 interacting protein in determining neuronal fate in acute injury VANDERBILT UNIVERSITY BethAnn McLaughlinPat R. Levitt StankowskiJeannette Nnot available.Jeannette N Stankowski
Retraction: Upregulation of C terminus of Hsc70-interacting protein attenuates apoptosis and procoagulant activity and facilitates brain repair after traumatic brain injurydoi:10.3389/fnins.2023.1330870[This retracts the article DOI: 10.3389/fnins.2020.00925.].Frontiers Editorial Office...
Expression of FMR1 inversely correlated with expression of the C-terminus of Hsc70-interacting protein (CHIP) and, based on the known activity of CHIP in protein homeostasis, we suggest that CHIP regulates expression of FMR1. CHIP ubiquitinated FMR1 for proteasomal degradation in a molecular ...