The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation. J Biol Chem. 2012; 287:15996-16006. [PubMed: 22427670]AHMED S F, DEB S, PAUL I, et al. Th
Upregulation of C Terminus of Hsc70-Interacting Protein Attenuates Apoptosis and Procoagulant Activity and Facilitates Brain Repair After Traumatic Brain Injury Frontiers in neuroscience (2020) -2Comments pubmed: 33013306 doi: 10.3389/fnins.2020.00925 issn: 1662-453x issn: 1662-4548 ...
The U-box E3 ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein) binds Hsp90 and/or Hsp70 via its tetratricopeptide repeat (TPR), facilitating ubiquitination of the chaperone-bound client proteins. Mechanisms that regulate the activity of CHIP are, at present, poorly understood. We ...
Fan M, Park A, Nephew KP (2005) CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. Mol Endocrinol 19(12):2901–2914. doi:10.1210/me.2005-0111 Article CAS PubMed Google Scholar Fuino L, Bali P, Wittmann S...
Anti-Heat shock protein A binding protein 2 (c-terminal) Anti-C terminus of HSC70-interacting protein (CHIP) Anti-Serologically defined colon cancer antigen 7 Anti-UBOX1 Anti-Water channel protein CHIP29 Anti-STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase ...
There are, however, other possible roles of CypD in the mitochondria which may or may not be linked with the MPTP. Alpha synuclein (αSyn) is shown here to interact directly with CypD via its acidic proline-rich C-terminus region and binding at the putative ligand binding pocket of CypD....
免疫原:KLHconjugatedsyntheticpeptidederivedfromhumanGAD65C-terminus 保质期:详见说明书 标记物:详见说明书 包装规格:0.1ml/100μg0.2ml/200μg 抗原来源:Rabbit 适应物种:详见说明书 克隆性:否 标识物:详见说明书 形态:详见说明书 保存条件:详见说明书 ...
Both C-terminus truncation mutant and full-length SR-BI showed no effect on IgM production in the CRISPR SR-BI knockout cells expressing C-terminus truncation mutant of SR-BI or full-length SR-BI (Supplementary Fig. 8B). B2.7 restoration promoted IgM production while B7.2/CD8 chimera, ...
The BRCA1 tumor suppressor encodes a polypeptide with two recognizable protein motifs: a RING domain near the N terminus and two tandem BRCT domains at the C terminus. Studies of tumor-associated mutations indicate that the RING and BRCT sequences are required for BRCA1-mediated tumor suppression...
1) C-terminus of Hsc70 interacting protein Hsc70羧基末端反应蛋白2) carboxyl-terminal protease 羧基末端蛋白酶 1. Sequence alignment showed that GhCtp was highly homo-(logous) to a family of carboxyl-terminal proteases (Ctp) from other species. GhCtp蛋白与拟南芥和水稻中的一类羧基末端蛋白酶...