本发明属于生物医药领域,具体涉及rtks/ras/raf/c-myc信号通路抑制剂的新用途。 背景技术: 1、铁死亡(ferroptosis)是一种非凋亡性细胞死亡机制,其发生依赖于具有氧化还原活性的金属铁。细胞内游离铁或含铁酶与氧气和含有多不饱和脂肪酸(pufa)的脂质反应,生成高水平的膜脂质过氧化物,这是铁死亡区别于其他形式细胞死亡...
Inhibiting miR-142-5p significantly decreased the ferroptosis-suppressing effect mediated by c-Myc. Through a combination of computational and experimental approaches, HOXA5 was identified as a key downstream target gene of miR-142-5p. Overexpression of miR-142-5p suppressed HOXA5 expression, leading...
Alteration or abnormal activation of RTKs have been recurrently observed and recognized as an important driving factor in the progression of many human cancers. Ferroptosis, an iron-dependent form of regulated necrosis triggered by the accumulation of le
Ferroptosis, a newly identified form of regulated cell death triggered by small molecules or specific conditions, plays a significant role in virus-associated carcinogenesis. However, whether tumours arising after high-risk HPV integration are associated with ferroptosis is unexplored and remains enigmatic...
CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression Article Open access 22 January 2024 Data availability The data that support the findings of this study are available from the corresponding authors upon reasonable request. RNA-seq data discussed in this paper...
The impact of Sodium Houttuyniae (SH) on lipopolysaccharide (LPS)-induced ALI has been investigated extensively. However, it remains ambiguous whether ferroptosis participates in this process. This study aimed to find out the impacts and probable mechani
Epigenetic repression of BRD4 by JQ1 was recently reported to induce ferroptosis by altering the expression of multiple ferroptosis-associated genes [25]. Additionally, treatment of various pancreatic cancer cell lines with the iron chelator deferasirox (DFX) reduced RAC1 and Cdc42 activity and ...
Emerging mechanisms and targeted therapy of ferroptosis in cancer 2021, Molecular Therapy Citation Excerpt : Due to its significant role in reducing lipid ROS accumulation on membrane lipids, GPX4 functions as the main regulator of ferroptosis. ACSL4 (acyl-CoA synthetase long chain family member 4)...
Colorectal cancer (CRC) is the second most common malignant tumor worldwide, and its incidence rate increases annually. Early diagnosis and treatment are crucial for improving the prognosis of patients with colorectal cancer. Circular RNAs are noncoding
Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation Free Radic. Res. (2021), pp. 1-11, 10.1080/10715762.2021.1876856 View PDFView articleGoogle Scholar Eilers and Eisenman, 2008 M. Eilers, R.N. Eisenman Myc’s broad reach Genes Dev., 22 (2008), pp. 275...