Although it has been demonstrated that stimulation of c‑Maf inducing protein (CMIP) expression is involved in podocyte damage, the molecular events during this process remain unclear. In the current study, CMIP‑induced proximal signaling was investigated by focusing on its effect on cofilin‑...
In naive T cells, Lck exerts a negative control on the ERK/MAPK pathway. We show that c-mip (c-maf inducing protein) interacts with the p85 subunit of PI3 kinase and inactivates Lck, which results in Erk1/2 and p38 MAPK activation. This effect is not enough to activate AP1 given ...
Among them, the suppressor of IKBKE 1 (SIKE-1), which modulates the innate immunity response by suppressing virus-triggered activation pathways was upregu- lated, and the C-Maf inducing protein (CMIP) gene, which encodes a protein that plays a role in T-cell signalling pathway was ...
b, Incomplete depletion of c-MAF protein in RORγt+ Treg cells in Maf∆Treg mice shown by a representative flow cytometry graph from 3 independent experiments (left), and a compilation of mean fluorescence intensities (MFI) in RORγt− Treg cells and residual RORγt+ Treg cells (right...
and one of the several MM-related oncogenes. Such translocation frequently involves the MAF bZIP transcription factor (MAF), the fibroblast growth factor receptor 3 (FGFR3), the multiple myeloma SET domain (MMSET), and cyclin D1 and D3, leading to the upregulation of cyclin D protein [11...
and one of the several MM-related oncogenes. Such translocation frequently involves the MAF bZIP transcription factor (MAF), the fibroblast growth factor receptor 3 (FGFR3), the multiple myeloma SET domain (MMSET), and cyclin D1 and D3, leading to the upregulation of cyclin D protein [11...
(c)TGF-β, IL-27 and ICOS differentially regulate IL-10 and IL-22 expression. By inducing c-Maf, a crucial transcriptional activator of IL-10 expression, TGF-β, IL-27 or ICOS promote IL-10 production in a variety of T cell subsets. On the other hand, all three factors potently ...
MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma Blood, 128 (25) (2016), pp. 2919-2930 CrossrefView in ScopusGoogle Scholar 7 X Mao, AK Stewart, R Hurren, et al. A chemical biology screen identifies glucocorticoids that regulate c-maf expression by ...
5l). Furthermore, co-IP assays of nuclear protein confirmed the interaction between SET1A and YAP, which was increased in ABHD5-knockdown cells compared with control cells (Fig. 5m). Collectively, the evidence presented here suggests that SET1A methylation of YAP is significantly increased under...