学位论文作者:**日期:加D年妇名日 中文摘要急性髓系白血病患者NPMl、FLT3和C.KIT基因突变的检测及预后分析中文摘要背景与目的NPMl突变和FLT3.ITD突变都是成人急性髓系白血病(AML)患者最常见的基因突变,均倾向于发生在正常核型AML(NK.AML)患者。正常核型伴单独NPM突变的AML预后较好,但当合并FLT3一ITD突变时预后较差...
PKC412是一 1eukemieMastCellLeukemiawiht AbnormalImmunophenotypenadC— 种有用的治疗试剂在46%核心结合因子白血病的C—Kit kitMutationD816VLeukemia& Lymphoma.2004;45:2295—2302 12TobiasM Kohi,Susanne~hnittger,JoachimW Ellwart,eta1.KITexon 中,酪蛋白激酶结构域(1KI)),近膜结构域,外显子8及内 8...
Applications Tested: This 104D2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sam...
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Sperm was obtained from semen straws provided by Umotest and Jura-Bétail breeding companies. DNA was extracted from blood samples with the Genisol Maxi-Prep kit (AbGene, UK) or from semen with a phenol/chloroform extraction (Miller, SA). DNA quality was assessed via 2% agarose gel ...
Dasatinib and radotinib are oral BCR-ABL tyrosine kinase inhibitors that were developed as drugs for the treatment of chronic myeloid leukemia. We report here that the c-KIT (CD117) targeting with dasatinib and radotinib promotes acute myeloid leukemia (
C-kit, a member of the RTK family, can be activated by its ligand, stem cell factor (SCF). Activation of c-kit signaling plays an important role in the proliferation, differentiation, migration and apoptosis of many kinds of cells, such as melanocyte, mast cell, Cajal cell and hemopoietic...
Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis. Numerous studies have conducted comprehensive analysis of c-di-GM
产品介绍The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which enc...