细胞成分主要集中在细胞外区域、转录因子复合物和染色质中(图 2C)。在分子功能类别中,差异 T 细胞标记基因主要与相同的蛋白质结合、信号受体结合和 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性相关(图 2D)。KEGG分析结果表明这些基因与癌症、人类T细胞白血病病毒1感染、细胞凋亡途径和IL-17信号通路显著相关(...
一项来自心脏和血液的单细胞RNA-seq数据集(GSE145154)包含1个正常样本、2个DCM样本和3个ICM样本。 三个批量RNA-Seq数据集包括正常、DCM和ICM样本:GSE79962、GSE5406 和 GSE57338。 GSE141910数据集,包括DCM和正常样本以及记录的LVEF信息,用于进一步的分析和验证。 分析流程图 文中对包含 ICM 和 DCM 的 HF 样品...
本期分享一篇整合单细胞和bulk-RNA seq数据分析的文章,揭示了抗原呈递和过程中的肿瘤相关成纤维细胞,并建立了前列腺癌的预测特征模型。文章于2024年1月发表于《Journal of Translational Medicine》,通讯作者为上海交通大学的韩邦旻教授,标题“Integrating single-cell and bulk RNA sequencing data unveils antigen presenta...
“Investigating Mechanisms of Response or Resistance to Immune Checkpoint Inhibitors by Analyzing Cell-Cell Communications in Tumors Before and After Programmed Cell Death-1 (PD-1) Targeted Therapy: An Integrative Analysis Using Single-cell RNA and Bulk-RNA Sequencing Data.” Oncoimmunology vol. 10,1...
今天小编和大家分享一篇22年11月发表在Frontiers in Immunology(IF:8.786)杂志的文章《Identification and validation of a signature based on macrophage cell marker genes to predict recurrent miscarriage by integrated analysis of single-cell and bulk RNA-sequencing》。作者通过单细胞和bulk RNA测序的联合分析,...
今天给大家分享一篇IF=7.7的非肿瘤的文章,2023年7月发表在Computers in Biology and Medicine:Identifying mitophagy-related genes as prognostic biomarkers and therapeutic targets of gastric carcinoma by integrated analysis of single-cell and bulk-RNA sequencing data,通过单细胞和Bulk RNA 测序数据的综合分析,鉴...
于2023年7月发表在Computers in Biology and Medicine上:Identifying mitophagy-related genes as prognostic biomarkers and therapeutic targets of gastric carcinoma by integrated analysis of single-cell and bulk-RNA sequencing data,整合单细胞和blukRNA测序数据鉴定线粒体自噬相关的基因作为胃癌的预后生物标志物和...
近日,美国俄勒冈健康与科学大学计算生物学组夏铮团队在Nature Biotechnology上发表了题为“Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data”的研究文章。研究团队开发了Scissor算法,可利用大量...
Single-cell RNA sequencingMETHYLATION SUBGROUPSMENINGIOMASCLASSIFICATIONMUTATIONSSYSTEMAKT1PurposeAccurate classification of cancer subgroups is essential for precision medicine, tailoring treatments to individual patients based on their cancer subtypes. In recent years, advances in high-throughput sequencing ...
今天小编和大家分享一篇22年11月发表在Frontiers in Immunology(IF:8.786)杂志的文章《Identification and validation of a signature based on macrophage cell marker genes to predict recurrent miscarriage by integrated analysis of single-...