Broad spectrum amino acid racemases (Bsrs) aid bacteria in producing non-canonical D-amino acids (NCDAA), which play significant functions in the modification of cell walls and biofilm breakdown. Bsr reversibly racemizes 10 of the 19 naturally occurring chiral amino acids (AAs), like both non...
Targeting common physicochemical properties of the viral fusion process, rather than specific receptor–ligand interactions, increases the potential of a therapeutic being broad spectrum. The viral membrane envelope, derived from host cells, represents a major new target for antiviral development. Targeting...
The putative HV68 ORF 73 gene product is significantly smaller than the KSHV LANA (314 versus 1,162 amino acids), being closer in size to the HVS ORF 73 gene product (407 amino acids) (39). Importantly, the structure of the HV68 ORF 73 transcript has not been determined, and it is...
REVIEWS The broad-spectrum antiviral functions of IFIT and IFITM proteins Michael S. Diamond1 and Michael Farzan2 Abstract | Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit ...
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Broad-Spectrum Antimicrobially Active CompoundsAn antimicrobially active compound of the formula[err](I)R[err] is selected from R[err]SO[err],H, and C[err]-C[err])alkyl;R and R[err] are independently selected from (C[err]-C[err])alkyl; R- and R[err] can be joined, together with...
Tigecycline, a member of a new class of antibiotics (glycylcyclines), has been shown to have a potent broad-spectrum activity against most gram-positive... CE Nord,E Sillerstrom,E Wahlund - 《Antimicrobial Agents & Chemotherapy》 被引量: 128发表: 2006年 Antimicrobial peptides derived from he...
Last, the endolysin exhibited a broad spectrum of lytic activity, as it was active on different species, mainly thermophilic lactobacilli but also lactococci, pediococci, Bacillus subtilis, Brevibacterium linens, and Enterococcus faecium. 展开
SARS-CoV-2 variants with adaptive mutations have continued to emerge, causing fresh waves of infection even amongst vaccinated population. The development of broad-spectrum antivirals is thus urgently needed. We previously developed two hetero-bivalent nanobodies (Nbs), aRBD-2-5 and aRBD-2-7, ...
www.nature.com/scientificreports OPEN received: 19 February 2015 accepted: 22 May 2015 Published: 19 June 2015 Preclinical optimization of a broad- spectrum anti-bladder cancer tri- drug regimen via the Feedback System Control (FSC) platform Qi Liu1,*, Cheng Zhang2,*, Xianting Ding3...