Brain metastases remain a significant challenge in the treatment of breast cancer patients due to the unique environment posed by the central nervous system. A better understanding of the biology of breast cancer cells that have metastasized to the brain is required to develop improved therapies. A...
内容提示: LETTERSGenes that mediate breast cancer metastasisto the brainPaulaD.Bos 1 ,XiangH.-F.Zhang 1 ,CristinaNadal 1 {,WeipingShu 1 ,RogerR.Gomis 1 {,DonX.Nguyen 1 ,AndyJ.Minn 2 ,Marc J. van de Vijver 3 , William L. Gerald 4 , John A. Foekens 5 & Joan Massague ´ 1...
A case of breast cancer metastasized to the brain 28 years after mastectomy in a 74-year-old woman is reported. The patient had undergone a mastectomy because of right breast cancer at the age of 46. Histopathological diagnosis of the tumor was invasive ductal carcinoma papillo-tubular type, ...
The researchers' next step is to initiate a collaboration with CAR T-cell experts to further understand how CAR T-cell therapy can be targeted to IL13Ra2. Eventually, Cittelly hopes to see clinical trials for patients withbreast cancerthat has metastasized to the brain, as they are currently...
A study led by researchers from the University of Arizona Cancer Center at UArizona Health Sciences identified a biological mechanism that could lead to more effective treatments for breast cancer that has metastasized to the brain. By studying the metabolic differences between primarybreast cancercells...
Furthermore, studies from patient-derived-xenograft models suggested that breast cancer cells that metastasized to the brain enhanced glucose oxidation, mitochondrial respiration, pentose-phosphate-pathway (PPP) and increased glutathione synthesis, when compared to the cells derived from the originating ...
I stopped by Mother’s house, She’d wanted to live at home to look after herself while she could...(在她被确诊后不久,我去了母亲的家。她想在力所能及的时候住在家里照顾自己……)”及第四段“As her health worsened, Mother eventually decided to stay with me in my house on the weekends...
Breast cancer that has metastasized to the brain presents difficult clinical challenges. This diagnosis comes with high mortality rates, largely due to com... DH Murrell,PJ Foster,AF Chambers - 《Journal of Molecular Medicine》 被引量: 28发表: 2014年 加载更多来源...
Breast cancer (BC) is the most frequently invasive malignancy and the leading cause of tumor-related mortality among women worldwide. Cancer metastasis is a complex, multistage process, which eventually causes tumor cells to colonize and grow at the meta
The most devastating feature of cancer cells is their ability to metastasize to distant sites in the body. HER2 + and TN breast cancers frequently metastasize to the brain and stay potentially dormant for years until favorable conditions support their