The experiments show that the best method to be used in the classification of breast cancer subtypes is the SVM with linear kernel, which presented an F1 score of 0.98 for the Basal subtype and 0.90 for the Her 2 subtype, the two subtypes with worse prognosis, respectively...
Here, we aimed to evaluate the effectiveness of combining global and local mammographic features by using Vision Transformer (ViT) and Convolutional Neural Network (CNN) to classify molecular subtypes in breast cancer.The feature values for binary classification were calculated using the ViT and ...
These subtypes were distinct from standard molecular subtyping and they could be used to refine the classification system. References Santagata, S. et al. Taxonomy of breast cancer based on normal cell phenotype predicts outcome. J. Clin. Invest. 124, 859–870 (2014) Article CAS Google Scholar...
A clinically important subtask, Luminal disease vs Non-Luminal disease (ER+ vs ER−), was considered for further analysis of the classification performance of the proposed model as this defines whether or not a cancer will be susceptible to endocrine therapy. In this setting, the MDL-IIA mod...
Among 123,780 early breast cancers from the California Cancer Registry, the surrogate classification using ER/PgR/HER-2 and tumor grade showed a variability in survival among HER-2 subtypes within each stage of disease, and while survival was superior across all the stages for ER/PgR positive/...
breast cancer subtypes, related to energy metabolism, cell growth, mRNA translation and cell–cell communication. Furthermore, we derived a signature of 19 proteins, which differ between the breast cancer subtypes, through support vector machine (SVM)-based classification and feature selection. ...
Here, we present an analysis of the validity of histological grade as a prognostic factor and a consensus view on the significance of histological grade and its role in breast cancer classification and staging systems in this era of emerging clinical use of molecular classifiers....
How many molecular subtypes? Implications of the unique tumor principle in personalized medicine Cancers are complex multifactorial diseases. For centuries, conventional organ-based classification system (i.e., breast cancer, lung cancer, colon cancer,... S Ogino,CS Fuchs,E Giovannucci - 《Expert ...
Breast cancer is the leading cause of cancer death in women in the world [1,2]. Breast cancer classification is based on immunohistochemical expression of specific receptors (the oestrogen (ER), progesterone (PR) and HER2 receptors). Using a molecular classification scheme, subtypes may be classi...
Previous studies demonstrated breast cancer tumor tissue samples could be classified into different subtypes based upon DNA microarray profiles. The most recent study presented evidence for the existence of five different subtypes: normal breast-like, ba