Two Cases of Breast Cancer Presented with Skin Metastasis as First SignsZindancı, İlkinCan, BurçeZemheri, EbruKavala, Mukaddes
New molecular insights challenge the traditional model of metastasis, and indicate that the metastatic capacity of breast tumours is an inherent feature, and not necessarily a late, acquired phenotype. Local breast cancer might have a 'non-metastatic, good-prognosis' stem cell of origin; metastasizin...
Here, we discuss the molecular basis of breast cancer metastasis and the challenges in personalization of treatment. The instability of metastatic tumors remains a leading obstacle to personalization, because information from a patient's primary tumor may not accurately reflect the metastasis, and one ...
Orthotopic or ectotopic implantation of cancer cells in the skin or mammary fat pad, with the formation of primary tumors and the subsequent formation of metastasis, in part resembles the multiple stages involved in malignant breast cancer development in patients [16]. In contrast, tail vein ...
Metastatic breast cancer Organoids PDTO Genomic Proteomic multi-OMICS 1. Introduction Metastatic progression is the primary cause of cancer mortality, thus there is no exception to metastatic breast cancer (mBC), as more than 90 % of the cancer-related deaths are a result of metastatic [1], ...
Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice Tumor-derived extracellular vesicles (EVs) critically regulate tumor development and progression. Here the authors show that, in a mouse model of breast cancer, miR-9-5p-loaded EVs...
Lung cancer is one of the most common cancers in America. Frequent sites of metastasis include the Hilar lymph nodes, adrenal glands, liver, brain, and bone. The following case report is of a primary lung cancer with metastases to the breast and skin. Case. A 48-year-old African American...
U.S. researchers identify gene in breast cancer pathway (File photo) The findings could help predict whether breast tumors will metastasize and also reveal potential drug targets for preventing metastasis, the university announced here on Tuesday. ...
The molecular basis for breast cancer metastasis to the brain is largely unknown12. Brain relapse typically occurs years after the removal of a breast tumour2,3,4, suggesting that disseminated cancer cells must acquire specialized functions to take over this organ. Here we show that breast cancer...
Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-associated inflammatory microenvironment aids tumor cells in metastatic colonization in lungs. Here, we show that tumor-secreted protease cathepsin C (CTSC) promotes breast-to-lung metastasis by regulating recruitment of...