Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged...
Logos on social media are changed to reflect support, which is awesome, but not everyone is telling the stories. This month, we are. Four brave women fromMinnesotaandIowasat with me and told me about their unique breast cancer journey. Today, you get to hear from our youngest breast cancer...
Breast Cancer-Derived Human CAFs Display Enhanced Glycolytic Activity We evaluated the metabolic rewiring of human breast CAFs and established a catalog of fibroblasts cultured from image-guided biopsies of breast tissue from women undergoing imaging evaluation of clinical and/or screen-detected breast abn...
Breast cancer Manual cold cap training case report Patient experience 1. Introduction Alopecia is a common and emotionally distressing adverse effect of curative-intent chemotherapy regimens in early stage breast cancer, resulting in physical and psychological quality of life (QOL) impact. (Macquart-Mou...
Here, we demonstrate that over-expression of WHSC1L1 is linked to over-expression of ERα in SUM-44 breast cancer cells and in primary human breast cancers. Knock-down of WHSC1L1, particularly WHSC1L1-short, had a dramatic effect on ESR1 mRNA and ERα protein levels. SUM-44 cells do ...
The MDA-MB-231 human breast cancer cell line was purchased from the American Type Culture Collection (ATCC) and used within 6 months of obtaining from ATCC. This cell line was tested and authenticated by ATCC using two independent methods: the ATCC cytochrome C oxidase I PCR assay, and short...
However, the role of PIWI in cancer remains elusive. Here we report that one of the four PIWI proteins in humans, PIWIL4, is highly expressed in both breast cancer tissues and the cytoplasm of MDA-MB-231 cells derived from breast cancer. Reducing PIWIL4 expression drastically impairs the ...
Using Boyden chamber membranes coated with type IV collagen, we show here that type IV collagen activates both DAAM1 and Ras homolog family member A (RHOA) and promotes haptotaxis of MDA-MB-231 and MDA-MB-453 breast cancer cells, a process abolished by treatment with the integrin αvβ3 ...