In this chapter, biology, diagnosis, prognostic factors, and treatments of MBC will be the focus.Introduction to Cancer Metastasisdoi:10.1016/B978-0-12-804003-4.00002-5Wakako TsujiJan A Plock
Bone is the most common site for breast cancer metastasis, with around 70% of breast cancer patients with metastasis experiencing distant bone metastasis during the disease progression [16]. The presence of advanced metastatic disease significantly impacts bone functionality, contributing to the rapid pr...
E-cadherin, allows breast cancer cells to survive as they travel through the body and form new tumors, a process termed metastasis. Their conclusions, obtained through laboratory experiments and in mouse models, help explain how metastasis works in the most common form of breast cancer, invasive...
Breast cancer (BC) is the most frequently invasive malignancy and the leading cause of tumor-related mortality among women worldwide. Cancer metastasis is a complex, multistage process, which eventually causes tumor cells to colonize and grow at the metastatic site. Distant organ metastases are the...
Breast cancer is the most common malignancy in women in the USA, and the second cause of cancer deaths after lung cancer; metastasis is the major cause of morbidity and mortality in breast cancer patients. Brain metastasis is an increasingly common complication in breast cancer patients, possibly...
Breast cancer is the most common cancer among women around the world (Althuis et al, 2005), and 40% of the women diagnosed with breast cancer will progress to metastatic disease (Berkowitz et al, 2000). Current treatment options for localised breast cancer include surgical resection of the pr...
1. Understanding Breast Cancer 1.1 Definition Breast cancer is defined as the uncontrolled growth of abnormal cells in the breast tissue. These cells have the potential to invade surrounding tissues and spread to other parts of the body, a process known as metastasis. 1.2 Risk Factors Several ris...
This review briefly introduces the metabolic changes in cancer with particular focus on breast cancer. Keywords: breast cancer; metabolomics; metabolites; glycolysis 1. Introduction Breast cancer is the most common cancer in women and it is one of the leading causes of cancer-related death among ...
Breast cancer includes several types: Ductal Carcinoma In Situ (DCIS), a non-invasive form; Invasive Ductal Carcinoma (IDC), the most common and aggressive; Invasive Lobular Carcinoma (ILC), starting in milk glands; and rarer forms like Inflammatory Breast Cancer (IBC), Medullary, Mucinous, and...
Breast cancer is the second most common diagnosed cancer in both sexes combined, while it is the leading cause of female cancer deaths globally [1]. Breast cancer is a heterogeneous disease, varying with respect to etiology, prognosis, and response to therapy [2]. Cancer is commonly described...