e12513#Background:The Breast Cancer Index (BCI) is a gene expression-based biomarker that reports two results: BCI Predictive [BCI (H/I)], which predicts benefit from extended endocrine therapy (EET), and BCI Prognostic, which combines the Molecular Grade Index (MGI) with BCI (H/I) to ...
aClinical information of breast cancer patients involved in the current study.bThe t-distributed stochastic neighbor embedding (t-SNE) projection of the immune cell atlas constructed from all patient samples. Each dot represents a cell, and major cell types are marked according to Supplementary Fig....
Breast cancer (BC) occurs when breast cells develop abnormally and grow out of control, forming a malignant tumor that can spread to other parts of the body.[1] BC that started off in the lobules is known as lobular carcinoma, while the one that developed from the ducts is called ductal...
Circulating tumour DNA (ctDNA) allows tracking of the evolution of human cancers at high resolution, overcoming many limitations of tissue biopsies. However, exploiting ctDNA to determine how a patient’s cancer is evolving in order to aid clinical decisions remains difficult. This is because ctDN...
Classification of Breast Cancer According to ERBB2 Immunohistochemistry Scores JAMA Oncology Comment & Response September 1, 2023 See More About Breast Cancer Cancer Biomarkers Women's Health Cancer Genetics Oncology Trending ERBB2-Low Breast Cancer JAMA Oncology Patient Information February 23, 2023 Agent...
Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by absence of estrogen (ER) receptor, progesterone (PR) receptor, and human epidermal growth factor-2 (HER-2) receptor. From: International Journal of Pharmaceutics, 2021 ...
In discussions with the patient prior to DCIS or early stage invasive breast cancer the physician must give the patient enough information with which to make a decision on radiotherapy which weighs the risk of (salvageable) local recurrence against the risk of lifelong lymphedema.I raised this issu...
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilitiesYi-Zhou Jiang, Ding Ma, Xi Jin, Yi Xiao, Ying Yu, Jinxiu Shi, Yi-Fan Zhou, Tong Fu, Cai-Jin Lin, Lei-Jie Dai, Cheng-Lin Liu, Shen Zhao,...
Cytotoxic chemotherapy and/or endocrine therapy after surgical removal and/or radiotherapy of the primary tumour. Adjuvant therapy is used to ensure that all microscopic disseminated cancer cells are destroyed. PROGNOSTIC MARKER A characteristic of a patient or tumour at the time of diagnosis that can...
Granular patient subtyping is particularly useful in the domain of cancer diagnosis and management– it has long been established that heterogeneity at the genomic and cellular level gives rise to diverse subtypes of cancers that respond differently to treatment, so the use of precision medicine whenev...