I discuss several chemotherapy protocols used in the treatment of adjuvant breast cancer, such as the AC, ACT, CMF, FEC, DAC, TDC, and DCARBT protocols, among others. I also discuss the protocols indicated for the treatment of locally advanced breast cancer and advanced breast cancer with ...
Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, that c
News & Views24 Jan 2025Nature Cancer P: 1-2 Menstrual cycle linked to breast cancer chemotherapy response According to preclinical studies and a retrospective clinical analysis, the menstrual cycle may influence the breast cancer response to neoadjuvant chemotherapy — suggesting that treatment could be...
Metaplastic breast cancer is a highly chemoresistant breast cancer subtype with limited therapeutic options. Here, the authors report that the NOS inhibitor, L-NMMA, sensitises metaplastic breast cancer to a selective PI3K inhibitor, alpelisib, and taxane chemotherapy via repression of c-JUN mediated...
Mortality from breast cancer is almost exclusively a result of tumor metastasis and resistance to therapy and therefore understanding the underlying mechanisms is an urgent challenge. Chemotherapy, routinely used to treat breast cancer, induces extensive
adenocarcinoma cells, SKOV3 (ovarian cancer) cells, AGS (gastric adenocarcinoma) cells, HEK-293 (human embryonic kidney cell), MCR-5 (human lung fibroblast) cells, mouse breast cancer cell 4T1 were obtained from American Type Culture Collection (ATCC) and grown according to standard protocols. ...
Obesity has been reported as an adverse prognostic factor in breast cancer, but inconsistently, and under-treatment with chemotherapy may occur. We provide the first assessment of obesity and breast cancer outcomes in a population-based, multi-ethnic cohort of New Zealand patients treated with chemot...
Breast cancer prevention: a summary of the chemoprevention trial with tamoxifen. PURPOSE/OBJECTIVES: To review the Breast Cancer Prevention Trial, which is testing tamoxifen as a chemoprevention agent. DATA SOURCES: Published articles and books; National Surgical Adjuvant Breast Project protocols. DATA ...
not responding to the initial 2 to 4 cycles of chemotherapy and this could not be improved by changing the regimen. Nonetheless, response-guided therapy is a promising approach to optimize and individualize treatment for early breast cancer. An overview of the mentioned trials is given in Table3...
and 2017, before starting neoadjuvant chemotherapy, which will put them into menopause. Two-thirds of the women decided to harvest eggs, using the new, faster ovarian stimulation technique, before cancer treatment. The remainder decided against it, after receiving counseling from the fertility clinic...