The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation is disrupted. This imbalance causes osteolytic bone metastasis in breast cancer, which leads to bone pain, pathological fractures, spinal...
There is no established method for assessing the prognosis of patients with breast cancer and metastasis confined initially to bone. The medical records of 82 patients with breast cancer nad metastasis confined initially to bone were reviewed. The following variables were analyzed at the time when bo...
Breast cancer frequently metastasizes to the skeleton, interrupting the normal bone remodeling process and causing bone degradation. Osteolytic lesions are the end result of osteoclast activity; however, osteoclast differentiation and activation are mediated by osteoblast production of RANKL (receptor activat...
To investigate any rational relation between breast cancer metastasis to various organs, a comprehensive comparison ran among the common upregulated hub genes designated to have a critical role in primary and bone-metastatic breast cancer and the hub genes which were responsible for breast cancer metas...
Stage IIIA breast cancer or locally advanced breast cancer, either: A tumor larger than 5 centimeters that has spread to the lymph nodes under the arm or near the breastbone Any size tumor with cancerous lymph nodes that stick to one another or nearby tissue Stage IIIB breast cancer. A tum...
CancerLandys K. Prognostic value of bone marrow biopsy in breast cancer. Cancer 1982; 495 13-5 18.Landys K. Prognosticvalue of bone marrowbiopsyin breast cancer.Cancer 1982;49:513-8.Landys K (1982) Prognostic value of bone marrow biopsy in breast cancer. Cancer 49:513-518...
Bone metastasis is a lethal consequence of breast cancer. Here we used single-cell transcriptomics to investigate the molecular mechanisms underlying bone metastasis colonization—the rate-limiting step in the metastatic cascade. We identified that lymphotoxin-β (LTβ) is highly expressed in tumour ce...
The prognosis for patients with primary breast cancer involving multiple axillary lymph nodes is poor. Only about 30% of patients remain disease-free at 5 ... DD Hurd,WP Peters - 《Journal of the National Cancer Institute Monographs》 被引量: 34发表: 1995年 Bone Health and Coronary Heart Di...
Cutaneous metastasis (CM) accounts for 5–30% of patients with breast cancer (BC) and presents unfavorable response to treatment and poor prognosis. A better understanding of the molecular alterations involved in metastasis is essential, which would help
Lymphatic mapping during cancer surgery can be used to find metastases to sentinel lymph nodes and guide therapies. Staging provides important information about the need for particular forms of therapy and the prognosis. BREAST CANCER Possible paths of lymphatic spreadA biopsy (obtained by fine ...